Journal article
Common molecular markers between circulating tumor cells and blood exosomes in colorectal cancer: a systematic and analytical review
Cancer management and research, Vol.11, pp.8669-8698
09/25/2019
DOI: 10.2147/CMAR.S219699
PMCID: PMC6768129
PMID: 31576171
Abstract
Nearly half of patients with colorectal cancer (CRC), the third leading cause of cancer deaths worldwide, are diagnosed in the late stages of the disease. Appropriate treatment is not applied in a timely manner and nearly 90% of the patients who experience metastasis ultimately die. Timely detection of CRC can increase the five-year survival rate of patients. Existing histopathological and molecular classifications are insufficient for prediction of metastasis, which limits approaches to treatment. Detection of reliable cancer-related biomarkers can improve early diagnosis, prognosis, and treatment response prediction and recurrence risk. Circulating tumor cells (CTCs) and exosomes in peripheral blood can be used in a liquid biopsy to assess the status of a tumor. Exosomes are abundant and available in all fluids of the body, have a high half-life and are released by most cells. Tumor-derived exosomes are released from primary tumors or CTCs with selective cargo that represents the overall tumor. The current systematic review highlights new trends and approaches in the detection of CRC biomarkers to determine tumor signatures using CTC and exosomes. When these are combined, they could be used to guide molecular pathology and can revolutionize detection tools. Relevant observational studies published until July 24, 2019 which evaluated the expression of tumor markers in CTCs and exosomes were searched in PubMed, Scopus, Embase, and ISI Web of Science databases. The extracted biomarkers were analyzed using String and EnrichR tools.
Details
- Title: Subtitle
- Common molecular markers between circulating tumor cells and blood exosomes in colorectal cancer: a systematic and analytical review
- Creators
- Somayeh Vafaei - Iran University of Medical SciencesFahimeh Fattahi - Iran University of Medical SciencesMarzieh Ebrahimi - Royan InstituteLeila Janani - Iran University of Medical SciencesAhmad Shariftabrizi - Memorial Sloan Kettering Cancer CenterZahra Madjd - Iran University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Cancer management and research, Vol.11, pp.8669-8698
- DOI
- 10.2147/CMAR.S219699
- PMID
- 31576171
- PMCID
- PMC6768129
- NLM abbreviation
- Cancer Manag Res
- ISSN
- 1179-1322
- eISSN
- 1179-1322
- Publisher
- Dove
- Alternative title
- Vafaei et al
- Language
- English
- Date published
- 09/25/2019
- Academic Unit
- Radiology
- Record Identifier
- 9984318792102771
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