Journal article
Common variants at 6q22 and 17q21 are associated with intracranial volume
Nature genetics, Vol.44(5), pp.539-544
05/01/2012
DOI: 10.1038/ng.2245
PMCID: PMC3618290
PMID: 22504418
Abstract
During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study in 8,175 community-dwelling elderly did not reveal any genome-wide significant associations (p<5*10
Details
- Title: Subtitle
- Common variants at 6q22 and 17q21 are associated with intracranial volume
- Creators
- M. Arfan Ikram - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsMyriam Fornage - Institute of Molecular Medicine and Human Genetics Center, University of Texas, Houston Health Sciences Center, Houston, TX, USAAlbert V Smith - Icelandic Heart Association, Kopavogur, IcelandSudha Seshadri - Department of Neurology, Boston University School of Medicine, Boston, MA, USAReinhold Schmidt - Department of Neurology, Medical University Graz, AustriaStéphanie Debette - Department of Neurology, Boston University School of Medicine, Boston, MA, USAHenri A Vrooman - Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsSigurdur Sigurdsson - Icelandic Heart Association, Kopavogur, IcelandStefan Ropele - Department of Neurology, Medical University Graz, AustriaH. Rob Taal - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsDennis O Mook-Kanamori - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsLaura H Coker - Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USAW.T Longstreth - Department of Neurology and Epidemiology, University of Washington, Seattle, WA, USAWiro J Niessen - Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsAnita L DeStefano - Department of Neurology, Boston University School of Medicine, Boston, MA, USAAlexa Beiser - Department of Neurology, Boston University School of Medicine, Boston, MA, USAAlex P Zijdenbos - Biospective Inc, Montreal, CanadaMaksim Struchalin - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsClifford R Jack - Department of Radiology, Mayo Clinic, Rochester, MN, USAFernando Rivadeneira - Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsAndre G Uitterlinden - Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsDavid S Knopman - Department of Neurology, Mayo Clinic, Rochester, MN, USAAnna-Liisa Hartikainen - Institute of Clinical Medicine, Obstetrics and Gynecology, University of Oulu, Oulu, FinlandCraig E Pennell - School of Women’s & Infant’s Health, University of Western Australia, Crawley, AustraliaElisabeth Thiering - Institute of Epidemiology I, Helmholtz Zentrum Munchen - German Research Centre for Environmental Health, Neuherberg, GermanyEric A.P Steegers - Department of Obstetrics and Gynaecology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsHakon Hakonarson - Center for Applied Genomics, Abramsom Research Center, The Children’s Hospital of Philadelphia, Philadelphia, USAJoachim Heinrich - School of Women’s & Infant’s Health, University of Western Australia, Crawley, AustraliaLyle J Palmer - Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, University of Toronto, Toronto, CanadaMarjo-Riitta Jarvelin - Department of Epidemiology and Biostatistics, School of Public Health, MRC-HPA Centre for Environmental and Health, Faculty of Medicine, Imperial College, London, UKMark I McCarthy - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UKStruan F.A Grant - Center for Applied Genomics, Abramsom Research Center, The Children’s Hospital of Philadelphia, Philadelphia, USABeate St Pourcain - MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UKNicholas J Timpson - MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UKGeorge Davey Smith - MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UKUlla Sovio - Department of Epidemiology and Biostatistics, School of Public Health, MRC-HPA Centre for Environmental and Health, Faculty of Medicine, Imperial College, London, UKMike A Nalls - Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, Bethesda, MD, USARhoda Au - Department of Neurology, Boston University School of Medicine, Boston, MA, USAAlbert Hofman - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsHaukur Gudnason - Icelandic Heart Association, Kopavogur, IcelandAad van der Lugt - Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsTamara B Harris - Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USAWilliam M Meeks - Department of Medicine (Geriatrics) and Neurology, University of Mississippi Medical Center, Jackson, MS, USAMeike W Vernooij - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsMark A van Buchem - Department of Radiology, Leiden University Medical Center, Leiden, The NetherlandsDiane Catellier - Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USAVincent W.V Jaddoe - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsVilmundur Gudnason - Icelandic Heart Association, Kopavogur, IcelandB. Gwen Windham - Department of Medicine (Geriatrics) and Neurology, University of Mississippi Medical Center, Jackson, MS, USAPhilip A Wolf - Department of Neurology, Boston University School of Medicine, Boston, MA, USACornelia M van Duijn - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsThomas H Mosley - Department of Medicine (Geriatrics) and Neurology, University of Mississippi Medical Center, Jackson, MS, USAHelena Schmidt - Institute of Molecular Biology and Biochemistry, Medical University Graz, AustriaLenore J Launer - Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USAMonique M.B Breteler - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsCohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) ConsortiumCharles DeCarli - Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA, USAEarly Growth Genetics (EGG) Consortium
- Contributors
- Jeffrey C Murray (Contributor) - University of Iowa, Dental Research
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.44(5), pp.539-544
- DOI
- 10.1038/ng.2245
- PMID
- 22504418
- PMCID
- PMC3618290
- NLM abbreviation
- Nat Genet
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Grant note
- N01 AG012100 || AG / National Institute on Aging : NIA
- Language
- English
- Date published
- 05/01/2012
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025471702771
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