Journal article
Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and potentially other non-Hodgkin lymphoma subtypes
British journal of haematology, Vol.159(5), pp.572-576
10/01/2012
DOI: 10.1111/bjh.12070
PMCID: PMC3614403
PMID: 23025533
Abstract
A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10−3). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.
Details
- Title: Subtitle
- Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and potentially other non-Hodgkin lymphoma subtypes
- Creators
- Susan L. Slager - Mayo ClinicNicola J. Camp - University of UtahLucia Conde - University of California, BerkeleyTait D. Shanafelt - Mayo ClinicSara J. Achenbach - Mayo ClinicKari G. Rabe - Mayo ClinicNeil E. Kay - Mayo ClinicAnne J. Novak - Mayo ClinicTimothy G. Call - Mayo ClinicPaige M. Bracci - University of California, San FranciscoFenna MC Sille - University of California, BerkeleySylvia Sanchez - University of California, BerkeleyNicholas K. Akers - University of California, BerkeleyJulie M. Cunningham - Mayo ClinicDaniel J. Serie - Mayo ClinicShannon K. McDonnell - Mayo ClinicJose F. Leis - Mayo ClinicAlice H. Wang - Mayo ClinicJ. Brice Weinberg - Duke Medical CenterMartha Glenn - University of UtahBrian Link - University of IowaCeline M. Vachon - Mayo ClinicMark C. Lanasa - Duke UniversityChristine F. Skibola - University of California, BerkeleyJames R. Cerhan - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- British journal of haematology, Vol.159(5), pp.572-576
- DOI
- 10.1111/bjh.12070
- PMID
- 23025533
- PMCID
- PMC3614403
- NLM abbreviation
- Br J Haematol
- ISSN
- 0007-1048
- eISSN
- 1365-2141
- Grant note
- R03 CA089745 || CA / National Cancer Institute : NCI R01 CA154643 || CA / National Cancer Institute : NCI R01 CA134674 || CA / National Cancer Institute : NCI R01 CA045614-06 || CA / National Cancer Institute : NCI P50 CA097274 || CA / National Cancer Institute : NCI R01 CA122663 || CA / National Cancer Institute : NCI R01 CA104682 || CA / National Cancer Institute : NCI R01 CA092153 || CA / National Cancer Institute : NCI K08 CA134919 || CA / National Cancer Institute : NCI
- Language
- English
- Date published
- 10/01/2012
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984359921902771
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