Journal article
Community dynamics during de novo colonization of the nascent peri-implant sulcus
International journal of oral science, Vol.17(1), 37
04/29/2025
DOI: 10.1038/s41368-025-00367-7
PMCID: PMC12041454
PMID: 40301331
Abstract
Dental implants have restored masticatory function to over 100 000 000 individuals, yet almost 1 000 000 implants fail each year due to peri-implantitis, a disease triggered by peri-implant microbial dysbiosis. Our ability to prevent and treat peri-implantitis is hampered by a paucity of knowledge of how these biomes are acquired and the factors that engender normobiosis. Therefore, we combined a 3-month interventional study of 15 systemically and periodontally healthy adults with whole genome sequencing, fine-scale enumeration and graph theoretics to interrogate colonization dynamics in the pristine peri-implant sulcus. We discovered that colonization trajectories of implants differ substantially from adjoining teeth in acquisition of new members and development of functional synergies. Source-tracking algorithms revealed that this niche is initially seeded by bacteria trapped within the coverscrew chamber during implant placement. These pioneer species stably colonize the microbiome and exert a sustained influence on the ecosystem by serving as anchors of influential hubs and by providing functions that enable cell replication and biofilm maturation. Unlike the periodontal microbiome, recruitment of new members to the peri-implant community occurs on nepotistic principles. Maturation is accompanied by a progressive increase in anaerobiosis, however, the predominant functionalities are oxygen-dependent over the 12-weeks. The peri-implant community is easily perturbed following crown placement, but demonstrates remarkable resilience; returning to pre-perturbation states within three weeks. This study highlights important differences in the development of the periodontal and peri-implant ecosystems, and signposts the importance of placing implants in periodontally healthy individuals or following the successful resolution of periodontal disease.
Details
- Title: Subtitle
- Community dynamics during de novo colonization of the nascent peri-implant sulcus
- Creators
- Tamires Pereira Dutra - Department of Periodontics and Oral Medicine, University of Michigan - School of Dentistry. 1011 N. University Ave, Ann Arbor, MI, USANicolas Robitaille - The Ohio State UniversityKhaled Altabtbaei - University of AlbertaShareef M Dabdoub - Division of Biostatistics and Computational Biology, The University of Iowa College of Dentistry, Iowa City, IA, USA. shareef-dabdoub@uiowa.eduPurnima S Kumar - Department of Periodontics and Oral Medicine, University of Michigan - School of Dentistry. 1011 N. University Ave, Ann Arbor, MI, USA. kpurnima@umich.edu
- Resource Type
- Journal article
- Publication Details
- International journal of oral science, Vol.17(1), 37
- DOI
- 10.1038/s41368-025-00367-7
- PMID
- 40301331
- PMCID
- PMC12041454
- NLM abbreviation
- Int J Oral Sci
- ISSN
- 2049-3169
- eISSN
- 2049-3169
- Publisher
- Springer Nature; LONDON
- Grant note
- R56 DE033913 / NIDCR NIH HHS R56DE033913 / U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01 DE027857 / NIDCR NIH HHS R03 DE027492 / NIDCR NIH HHS
- Language
- English
- Date published
- 04/29/2025
- Academic Unit
- Dental Research; Periodontics
- Record Identifier
- 9984815910802771
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