Journal article
Community health assessment and monitoring in the pharmacy (CHAMP): Protocol for a randomized stepped-wedge trial of lung cancer screening in community pharmacies
Contemporary clinical trials, Vol.169, 108434
10/2026
DOI: 10.1016/j.cct.2026.108434
PMID: 42580402
Abstract
Despite widespread insurance coverage and USPSTF recommendations, less than 20% of eligible individuals undergo annual lung cancer screening nationally. This low uptake suggests that innovative screening modalities and referral pathways are needed. We hypothesize that utilizing community pharmacies for screening and connecting patients to either traditional imaging or novel, blood-based modalities will improve uptake among eligible patients.
We describe a multiphase study. First, during the initial phase, to assess the feasibility of community pharmacist-led lung cancer screening (LCS) and, subsequently, a randomized stepped-wedge trial expansion phase comparing pharmacist LCS intervention to usual care in ten community pharmacies. We plan to enroll 250 participants in the initial phase and 1000 participants in the expansion phase (500 participants in the usual care arm and 500 participants in the intervention arm). The primary endpoint is the proportion of LCS-eligible participants who receive a screening recommendation from a pharmacist and who both accept the recommendation and complete the screening.
This study will test the feasibility and efficacy of pharmacy-based LCS programs. By investigating an alternative LCS referral location and modality, our novel intervention seeks to supplement traditional primary care-based interventions to increase overall LCS rates. We hypothesize that this strategy can increase LCS rates 20% from baseline.
•Lung cancer screening has low uptake, only roughly 20% of eligible patients complete recommended screening.•Community pharmacies offer a novel, accessible referral pathway for lung cancer screening.•The stepped-wedge design described here provides a replicable framework for future trials of pharmacy-based preventive screening referral pathways.
Details
- Title: Subtitle
- Community health assessment and monitoring in the pharmacy (CHAMP): Protocol for a randomized stepped-wedge trial of lung cancer screening in community pharmacies
- Creators
- Emily Sadecki - University of IowaKorey A. Kennelty - University of IowaBrian J. Smith - University of IowaLaura Seegmiller - University of IowaRobert NicholsJames Hoehns - University of IowaStevie Veach - University of IowaCam Marsengill - University of IowaAlyssa Noble - University of IowaSarah LarsonJames PoockKim Baker-El Abiad - University of IowaBruno Policeni - University of IowaKalpaj R. Parekh - University of IowaJeffrey D. Quinlan - University of IowaJill Kolesar - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Contemporary clinical trials, Vol.169, 108434
- DOI
- 10.1016/j.cct.2026.108434
- PMID
- 42580402
- NLM abbreviation
- Contemp Clin Trials
- ISSN
- 1551-7144
- eISSN
- 1559-2030
- Publisher
- Elsevier Inc
- Grant note
- Eli Lily and Company
This study is funded by Eli Lily and Company.
- Language
- English
- Electronic publication date
- 08/11/2026
- Date published
- 10/2026
- Academic Unit
- Pharmacy; Public Health Administration; Oral Pathology, Radiology and Medicine; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Family and Community Medicine; Pharmacy Practice and Science; Injury Prevention Research Center; Cardiothoracic Surgery; Otolaryngology; Radiology; Pulmonary, Critical Care, and Occupational Medicine; Anatomy and Cell Biology; Obstetrics and Gynecology; Holden Comprehensive Cancer Center; Internal Medicine
- Record Identifier
- 9985218543202771
Metrics
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