Journal article
Comorbidities of Obsessive and Compulsive Symptoms in Huntington's Disease
The journal of nervous and mental disease, Vol.198(5), pp.334-338
05/01/2010
DOI: 10.1097/NMD.0b013e3181da852a
PMCID: PMC3164360
PMID: 20458194
Abstract
Although current reports document a high rate of obsessive and compulsive symptoms (O/Cs) in Huntington's disease (HD), there have been no studies published that have made an attempt to identify comorbidities of O/Cs in HD. We examined O/Cs in 1642 individuals with a diagnosis of HD. Of those endorsing significant O/Cs (27.2%), nearly one-quarter reported obtaining treatment for obsessive compulsive disorder. Individuals with HD and O/Cs were older, had poorer functioning, and a longer duration of illness than those without O/Cs. Individuals with HD and O/Cs endorsed significantly higher psychiatric comorbidities of depression, suicidal ideation, aggression, delusions, and hallucinations. Participants with the most severe O/Cs and worse performance on the Stroop task, a measure of executive function. Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan.
Details
- Title: Subtitle
- Comorbidities of Obsessive and Compulsive Symptoms in Huntington's Disease
- Creators
- Karen E. Anderson - University of Maryland, BaltimoreCarissa R. Gehl - Mayo Clin, Dept Psychiat, Rochester, MN USAKaren S. Marder - Columbia UniversityLeigh J. Beglinger - Univ Iowa, Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USAJane S. Paulsen - Univ Iowa, Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USAHuntington's Study Group
- Resource Type
- Journal article
- Publication Details
- The journal of nervous and mental disease, Vol.198(5), pp.334-338
- DOI
- 10.1097/NMD.0b013e3181da852a
- PMID
- 20458194
- PMCID
- PMC3164360
- NLM abbreviation
- J Nerv Ment Dis
- ISSN
- 0022-3018
- eISSN
- 1539-736X
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Grant note
- NS40068 / National Institutes of Health, National Institutes of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) CHDI Foundation, Inc R01NS040068 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 05/01/2010
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984293655502771
Metrics
21 Record Views