Journal article
Comorbidity burden and outcomes of older adults with acute promyelocytic leukemia: a National Cancer Database analysis of 2221 patients
Leukemia & lymphoma, Vol.64(3), pp.691-697
2023
DOI: 10.1080/10428194.2023.2165394
PMID: 36629003
Abstract
Association between comorbidity burden and patient outcomes has not been adequately investigated in acute promyelocytic leukemia (APL). We utilized the National Cancer Database to evaluate the association of the Charlson-Deyo Comorbidity Index (CCI) with one-month mortality and overall survival (OS) in adults ≥60 years with APL. One-month mortality was 16%, 24%, and 32%, and 3-year OS was 61%, 53%, and 38% for patients with CCI 0, 1, and ≥2, respectively. One-month mortality was higher for patients with CCI 1 (OR 1.67, 95% CI 1.29-2.16, p < .001) and CCI ≥ 2 (OR 2.31, 95% CI 1.70-3.13, p < .001) compared to patients with CCI 0. Patients with CCI 1 (HR 1.27, 95% CI 1.10-1.46, p < .001) and CCI ≥ 2 (HR 1.74, 95% CI 1.48-2.06, p < .001) had worse OS compared to patients with CCI 0. In conclusion, CCI is an independent predictor of survival outcomes in patients with APL.
Details
- Title: Subtitle
- Comorbidity burden and outcomes of older adults with acute promyelocytic leukemia: a National Cancer Database analysis of 2221 patients
- Creators
- Prajwal Dhakal - University of IowaElizabeth Lyden - University of Nebraska Medical CenterUtsav Joshi - Rochester General HospitalAvantika Pyakuryal - Pokhara UniversityKah Poh Loh - University of Rochester Medical CenterHeidi Klepin - Wake Forest UniversityVijaya Raj Bhatt - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Leukemia & lymphoma, Vol.64(3), pp.691-697
- Publisher
- Taylor & Francis
- DOI
- 10.1080/10428194.2023.2165394
- PMID
- 36629003
- ISSN
- 1042-8194
- eISSN
- 1029-2403
- Language
- English
- Electronic publication date
- 01/10/2023
- Date published
- 2023
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984361573302771
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