Comparative Analyses of the 9 Glycoprotein Genes Found in Wild-Type and Vaccine Strains of Varicella-Zoster Virus

Johnathan Storlie; Lucie Maresova; Wallen Jackson; Charles Grose

doi:10.1086/522127

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Comparative Analyses of the 9 Glycoprotein Genes Found in Wild-Type and Vaccine Strains of Varicella-Zoster Virus

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Comparative Analyses of the 9 Glycoprotein Genes Found in Wild-Type and Vaccine Strains of Varicella-Zoster Virus

Johnathan Storlie, Lucie Maresova, Wallen Jackson and Charles Grose

The Journal of infectious diseases, Vol.197(Supplement-2), pp.S49-S53

03/01/2008

DOI: 10.1086/522127

PMID: 18419408

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Abstract

The complete DNA sequences of wild-type and vaccine strains of varicella-zoster virus have been published and listed in GenBank. In this comparative genomic analysis, the sequences of the 9 glycoprotein open reading frames (ORFs) were compared. They included gE (ORF68), gI (ORF 67), gC (ORF14), gH (ORF37), gL (ORF60), gB (ORF31), gK (ORF5), gM (ORF50), and gN (ORF8 or ORF9A). After realignment on the basis of newer data, the corrected gB sequence was lengthened to include 931 residues. The data showed that there were glycoprotein polymorphisms that differentiated North American/European strains from Japanese strains—for example, an additional ATG codon in the gL of all Oka strains. Also, there were a small number of coding single-nucleotide polymorphisms present only in glycoproteins of vaccine strains. Because these changes were highly conserved, the structure of the glycoprotein was unlikely to be altered.

Details

Title: Subtitle: Comparative Analyses of the 9 Glycoprotein Genes Found in Wild-Type and Vaccine Strains of Varicella-Zoster Virus
Creators: Johnathan Storlie - Departments of Pediatrics and Microbiology, University of Iowa, Iowa City
Lucie Maresova - Departments of Pediatrics and Microbiology, University of Iowa, Iowa City
Wallen Jackson - Departments of Pediatrics and Microbiology, University of Iowa, Iowa City
Charles Grose - Departments of Pediatrics and Microbiology, University of Iowa, Iowa City
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.197(Supplement-2), pp.S49-S53
DOI: 10.1086/522127
PMID: 18419408
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: The University of Chicago Press
Language: English
Date published: 03/01/2008
Academic Unit: Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093502202771

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