Comparative Effectiveness of Published Interventions for Elderly Fall Prevention: A Systematic Review and Network Meta-Analysis

Peixia Cheng; Liheng Tan; Peishan Ning; Li Li; Yuyan Gao; Yue Wu; David C Schwebel; Haitao Chu; Huaiqiong Yin; Guoqing Hu

doi:10.3390/ijerph15030498

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Comparative Effectiveness of Published Interventions for Elderly Fall Prevention: A Systematic Review and Network Meta-Analysis

Journal article

Open access

Peer reviewed

Comparative Effectiveness of Published Interventions for Elderly Fall Prevention: A Systematic Review and Network Meta-Analysis

Peixia Cheng, Liheng Tan, Peishan Ning, Li Li, Yuyan Gao, Yue Wu, David C Schwebel, Haitao Chu, Huaiqiong Yin and Guoqing Hu

International journal of environmental research and public health, Vol.15(3), p.498

03/12/2018

DOI: 10.3390/ijerph15030498

PMCID: PMC5877043

PMID: 29534531

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Abstract

Falls are a major threat to older adults worldwide. Although various effective interventions have been developed, their comparative effectiveness remains unreported. A systematic review and network meta-analysis was conducted to determine the most effective interventions to prevent falls in community-dwelling adults aged 60 and over. Combined odds ratio (OR) and 95% credible interval (95% CrI) were calculated. A total of 49 trials involving 27,740 participants and 9271 fallers were included. Compared to usual care, multifactorial interventions (MFI) demonstrated the greatest efficacy (OR: 0.64, 95% CrI: 0.53 to 0.77) followed by interventions combining education and exercise (EDU + EXC) (OR: 0.65, 95% CrI: 0.38 to 1.00) and interventions combining exercise and hazard assessment and modification (EXC + HAM) (OR: 0.66, 95% CrI: 0.40 to 1.04). The effect of medical care performed the worst (OR: 1.02, 95% CrI: 0.78 to 1.34). Model fit was good, inconsistency was low, and publication bias was considered absent. The overall quality of included trials was high. The pooled odds ratios and ranking probabilities remained relatively stable across all sensitivity analyses. MFI and exercise appear to be effective to reduce falls among older adults, and should be considered first as service delivery options. Further investigation is necessary to verify effectiveness and suitableness of the strategies to at-risk populations.

Accidental Falls - prevention & control

Aged

Aged, 80 and over

Humans

Independent Living

Middle Aged

Preventive Health Services - methods

Treatment Outcome

Details

Title: Subtitle: Comparative Effectiveness of Published Interventions for Elderly Fall Prevention: A Systematic Review and Network Meta-Analysis
Creators: Peixia Cheng - Central South University
Liheng Tan - Central South University
Peishan Ning - Central South University
Li Li - Central South University
Yuyan Gao - Central South University
Yue Wu - Central South University
David C Schwebel - University of Alabama at Birmingham
Haitao Chu - University of Minnesota
Huaiqiong Yin - Central South University
Guoqing Hu - Central South University
Resource Type: Journal article
Publication Details: International journal of environmental research and public health, Vol.15(3), p.498
DOI: 10.3390/ijerph15030498
PMID: 29534531
PMCID: PMC5877043
NLM abbreviation: Int J Environ Res Public Health
ISSN: 1660-4601
eISSN: 1660-4601
Language: English
Date published: 03/12/2018
Academic Unit: Research Administration
Record Identifier: 9984949182302771

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