Journal article
Comparative Study With New Accuracy Metrics for Target Volume Contouring in PET Image Guided Radiation Therapy
IEEE transactions on medical imaging, Vol.31(11), pp.2006-2024
11/2012
DOI: 10.1109/TMI.2012.2202322
PMCID: PMC5570440
PMID: 22692898
Abstract
The impact of positron emission tomography (PET) on radiation therapy is held back by poor methods of defining functional volumes of interest. Many new software tools are being proposed for contouring target volumes but the different approaches are not adequately compared and their accuracy is poorly evaluated due to the ill-definition of ground truth. This paper compares the largest cohort to date of established, emerging and proposed PET contouring methods, in terms of accuracy and variability. We emphasize spatial accuracy and present a new metric that addresses the lack of unique ground truth. Thirty methods are used at 13 different institutions to contour functional volumes of interest in clinical PET/CT and a custom-built PET phantom representing typical problems in image guided radiotherapy. Contouring methods are grouped according to algorithmic type, level of interactivity and how they exploit structural information in hybrid images. Experiments reveal benefits of high levels of user interaction, as well as simultaneous visualization of CT images and PET gradients to guide interactive procedures. Method-wise evaluation identifies the danger of over-automation and the value of prior knowledge built into an algorithm.
Details
- Title: Subtitle
- Comparative Study With New Accuracy Metrics for Target Volume Contouring in PET Image Guided Radiation Therapy
- Creators
- Tony Shepherd - Turku PET Centre and Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandMika Teras - Turku PET Centre and Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandReinhard R Beichel - Department of Electrical & Computer Engineering and Internal Medicine, University of Iowa, USARonald Boellaard - Department of Nuclear Medicine & PET Research, VU University Medical Centre, Amsterdam, The NetherlandsMichel Bruynooghe - SenoCAD Research GmbH, GermanyVolker Dicken - Fraunhofer MEVIS-Institute for Medical Image Computing, Bremen, GermanyMark J Gooding - Mirada Medical, Oxford, UKPeter J Julyan - North Western Medical Physics, Christie Hospital NHS Foundation Trust, Manchester, UKJohn A Lee - Belgian FNRS and center for Molecular Imaging, Radiotherapy, and Oncology (MIRO), Université Catholique de Louvain, Brussels, BelgiumSébastien Lefevre - VALORIA Research Laboratory, University of South Brittany, FranceMichael Mix - Department of Radiation Oncology, University Freiburg Medical Centre, GermanyValery Naranjo - Labhuman Inter-University Research Institute for Bioengineering and Human Centered Technology, Valencia, SpainXiaodong Wu - Department of Electrical & Computer Engineering, University of Iowa, USAHabib Zaidi - Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, SwitzerlandZiming Zeng - Department of Computer Science, University of Aberystwyth, UKHeikki Minn - Turku PET Centre and Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
- Resource Type
- Journal article
- Publication Details
- IEEE transactions on medical imaging, Vol.31(11), pp.2006-2024
- DOI
- 10.1109/TMI.2012.2202322
- PMID
- 22692898
- PMCID
- PMC5570440
- NLM abbreviation
- IEEE Trans Med Imaging
- ISSN
- 0278-0062
- eISSN
- 1558-254X
- Publisher
- Institute of Electrical and Electronics Engineers
- Language
- English
- Date published
- 11/2012
- Academic Unit
- Electrical and Computer Engineering; Radiation Oncology
- Record Identifier
- 9984047995202771
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