Journal article
Comparative analysis of the Epstein-Barr virus encoded nuclear proteins of EBNA-3 family
Computers in biology and medicine, Vol.39(11), pp.1036-1042
11/01/2009
DOI: 10.1016/j.compbiomed.2009.08.006
PMID: 19762010
Abstract
It is known that the EBNA-3 family proteins (EBNA-3, -4 and -6, alternative nomenclature EBNA-3A, B and C correspondingly) show a limited sequence similarity.
We have analyzed EBNA-3 proteins both at the primary sequence and secondary structure levels. EBNA-3 and EBNA-4 were structurally more similar compared to other combinations with EBNA-6. We found “Stonin Homology Domain” profile in EBNA-4 and “Proline Rich Domain” in all EBNA-3 family of proteins. We have also found positive and negative charge clusters in all three proteins and mixed charge clusters in EBNA-3. Charged clusters are believed to play an important role in interactions with DNA or signaling proteins. Additionally, unique primary sequence repeats were found in all three proteins.
Details
- Title: Subtitle
- Comparative analysis of the Epstein-Barr virus encoded nuclear proteins of EBNA-3 family
- Creators
- Surya Pavan Yenamandra - Karolinska InstitutetRamakrishna Sompallae - Karolinska InstitutetGeorge Klein - Karolinska InstitutetElena Kashuba - Karolinska Institutet
- Resource Type
- Journal article
- Publication Details
- Computers in biology and medicine, Vol.39(11), pp.1036-1042
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.compbiomed.2009.08.006
- PMID
- 19762010
- ISSN
- 0010-4825
- eISSN
- 1879-0534
- Language
- English
- Date published
- 11/01/2009
- Academic Unit
- Pathology
- Record Identifier
- 9984622755402771
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