Journal article
Comparative evaluation of approach to cardiovascular care in neonatal encephalopathy undergoing therapeutic hypothermia
Journal of perinatology, Vol.42(12), pp.1637-1643
07/20/2022
DOI: 10.1038/s41372-022-01459-6
PMID: 35859183
Abstract
Objective To analyze the association between cardiovascular care and adverse outcome in infants undergoing therapeutic hypothermia for neonatal encephalopathy (NE). Study design This was a retrospective cohort study of 176 infants with NE and hypotension, admitted to the SickKids Hospital (Center A, n = 86) or Semmelweis University (Center B, n = 90). Result The lowest systolic/diastolic blood pressures were comparable amongst centers; however, proportion of cardiovascular support was lower in Center A (51% vs 97% in Center B). Overall rate of death or abnormal MRI (adverse outcome) were comparable between centers, although pattern differed with more basal ganglia injury in Center B. A 24-hour longer duration of cardiovascular support increased the odds for adverse outcome by 14%. Conclusion We demonstrated that management of hemodynamic instability in infants with NE was markedly different in two high-volume NICUs and showed that longer duration of cardiovascular medication is an independent risk factor for adverse outcome.
Details
- Title: Subtitle
- Comparative evaluation of approach to cardiovascular care in neonatal encephalopathy undergoing therapeutic hypothermia
- Creators
- Kata Kovacs - Semmelweis UniversityRegan E. Giesinger - University of IowaAndrea Lakatos - Semmelweis UniversityAttila J. Szabo - Semmelweis UniversityMiklos Szabo - Semmelweis UniversityAgnes Jermendy - Semmelweis UniversityPatrick J. McNamara - Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.42(12), pp.1637-1643
- Publisher
- Springer Nature
- DOI
- 10.1038/s41372-022-01459-6
- PMID
- 35859183
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Number of pages
- 7
- Grant note
- OTKA 135222 / Hungarian Scientific Research Fund; Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA)
- Language
- English
- Date published
- 07/20/2022
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984353942702771
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