Journal article
Comparative risk of hip fractures in elderly nursing home patients with depression using paroxetine and other selective serotonin reuptake inhibitors
Journal of Comparative Effectiveness Research, Vol.5(5), pp.461-473
08/01/2016
DOI: 10.2217/cer-2016-0009
PMCID: PMC4975023
PMID: 27426927
Abstract
To evaluate comparative safety of paroxetine and other selective serotonin reuptake inhibitors (SSRIs) for the risk of hip fractures.
A propensity score-matched retrospective cohort study was conducted using 2007-2010 Minimum Data Set linked Medicare data. Robust Cox proportional hazards model was used to evaluate the risk of hip fractures in depressed elderly nursing home residents.
Cox analysis did not find any significant difference in the risk of hip fractures for the paroxetine users (hazard ratio: 1.09; 95% CI: 0.91-1.32) when compared with other SSRIs. Results from the sensitivity analysis supported the main findings.
There was no differential risk of hip fractures between paroxetine and other SSRIs. Future studies are needed to evaluate other anticholinergic effects of paroxetine.
Details
- Title: Subtitle
- Comparative risk of hip fractures in elderly nursing home patients with depression using paroxetine and other selective serotonin reuptake inhibitors
- Creators
- Vishal BaliSatabdi ChatterjeeMichael L JohnsonHua ChenRyan M CarnahanRajender R Aparasu
- Resource Type
- Journal article
- Publication Details
- Journal of Comparative Effectiveness Research, Vol.5(5), pp.461-473
- DOI
- 10.2217/cer-2016-0009
- PMID
- 27426927
- PMCID
- PMC4975023
- NLM abbreviation
- J Comp Eff Res
- ISSN
- 2042-6305
- eISSN
- 2042-6313
- Publisher
- Future Medicine Ltd
- Language
- English
- Date published
- 08/01/2016
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9983995178002771
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