Comparative study of the antimicrobial efficacy of chlorhexidine gel, chlorhexidine solution and sodium hypochlorite as endodontic irrigants

Caio C R Ferraz; Brenda P F A Gomes; Alexandre A Zaia; Fabrício B Teixeira; Francisco J Souza-Filho

doi:10.1590/s0103-64402007000400004

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Comparative study of the antimicrobial efficacy of chlorhexidine gel, chlorhexidine solution and sodium hypochlorite as endodontic irrigants

Journal article

Open access

Comparative study of the antimicrobial efficacy of chlorhexidine gel, chlorhexidine solution and sodium hypochlorite as endodontic irrigants

Caio C R Ferraz, Brenda P F A Gomes, Alexandre A Zaia, Fabrício B Teixeira and Francisco J Souza-Filho

Brazilian dental journal, Vol.18(4), p.294

2007

DOI: 10.1590/s0103-64402007000400004

PMID: 18278298

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Abstract

The purpose of this study was to assess the in vitro the antimicrobial efficacy of chlorhexidine gluconate gel as an endodontic auxiliary chemical substance compared to sodium hypochlorite (NaOCl) and chlorhexidine gluconate solution. The antimicrobial efficacy of the tested substances was evaluated using the agar diffusion test. The growth inhibition zones produced by 0.2%, 1% and 2% chlorhexidine gel were evaluated against 5 facultative anaerobic bacteria and 4 pigmented Gram-negative anaerobes, and compared to the results obtained by NaOCl and chlorhexidine solution. The largest growth inhibition zones were produced when the test bacteria were in contact with 2% chlorhexidine gluconate gel (11.79 mm), being significantly different (p<0.05) from the growth inhibition zones produced by all NaOCl concentrations, including 5.25% (9.54 mm). However, there was no statistically significant difference (p>0.05) between the growth inhibition zones obtained with equal concentrations of chlorhexidine solution and gel. The results of this study indicate that, as far as its antimicrobial properties are concerned, chlorhexidine gel has a great potential to be used as an endodontic auxiliary chemical substance.

Materials Testing

Enterococcus faecalis - drug effects

Gels

Porphyromonas endodontalis - drug effects

Actinomyces - drug effects

Prevotella intermedia - drug effects

Humans

Streptococcus sobrinus - drug effects

Chlorhexidine - pharmacology

Root Canal Irrigants - administration & dosage

Colony Count, Microbial

Sodium Hypochlorite - administration & dosage

Root Canal Irrigants - pharmacology

Prevotella - drug effects

Chlorhexidine - analogs & derivatives

Solutions

Streptococcus sanguis - drug effects

Dental Disinfectants - pharmacology

Dental Disinfectants - administration & dosage

Chlorhexidine - administration & dosage

Sodium Hypochlorite - pharmacology

Staphylococcus aureus - drug effects

Porphyromonas gingivalis - drug effects

Details

Title: Subtitle: Comparative study of the antimicrobial efficacy of chlorhexidine gel, chlorhexidine solution and sodium hypochlorite as endodontic irrigants
Creators: Caio C R Ferraz - Department of Endodontics, School of Dentistry of Piracicaba, University of Campinas, Piracicaba, SP, Brazil. cferraz@fop.unicamp.br
Brenda P F A Gomes
Alexandre A Zaia
Fabrício B Teixeira
Francisco J Souza-Filho
Resource Type: Journal article
Publication Details: Brazilian dental journal, Vol.18(4), p.294
DOI: 10.1590/s0103-64402007000400004
PMID: 18278298
NLM abbreviation: Braz Dent J
eISSN: 1806-4760
Publisher: Brazil
Language: English
Date published: 2007
Academic Unit: Endodontics
Record Identifier: 9984066086502771

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