Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and non-recurrent glandular odontogenic cysts - A retrospective longitudinal cohort multicenter study

Alberto Peraza-Labrador; John Wright; Victoria Woo; Monica Kowalski; Kittiphoj Tikkhanarak; Nidhi Q. Handoo; Wattawan Wongpattaraworakul; Elizabeth Bilodeau; Felipe Nor; Molly Housley Smith; Matthew Kesterke; Hua Zhang; Patricia Barros; Madhu Shrestha

doi:10.1016/j.oooo.2025.08.010

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Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and non-recurrent glandular odontogenic cysts - A retrospective longitudinal cohort multicenter study

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Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and non-recurrent glandular odontogenic cysts - A retrospective longitudinal cohort multicenter study

Alberto Peraza-Labrador, John Wright, Victoria Woo, Monica Kowalski, Kittiphoj Tikkhanarak, Nidhi Q. Handoo, Wattawan Wongpattaraworakul, Elizabeth Bilodeau, Felipe Nor, Molly Housley Smith, …

Oral surgery, oral medicine, oral pathology and oral radiology, Vol.141(1), pp.86-95

01/2026

DOI: 10.1016/j.oooo.2025.08.010

PMID: 40962685

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Abstract

To analyze the clinicopathological profile of recurrent and non-recurrent glandular odontogenic cyst (GOC) through a longitudinal cohort multicenter study. This multicenter longitudinal cohort study investigates factors associated with GOC recurrence. Included in the study were patients with histologically confirmed GOC (per Fowler’s criteria), who experienced recurrence at least one year post-treatment. Controls were GOCs with a minimum of five years of recurrence-free follow-up. Histologic features, treatment rendered, and immunohistochemical staining results for CK13, CK19, and Ki-67 were documented. Eleven recurrent cases (6 males, 5 females; mean age, 56.09 years) were analyzed. The anterior mandible was the most frequently affected site (45.5%), followed by the posterior and anterior maxilla (27.1%, each). The average follow-up was 36.1 months. Recurrence was significantly associated with multiple compartments and the absence of apocrine snouting (p =0.013, p = 0.034, respectively). The majority of the primary GOCs that later recurred were treated with enucleation (73%). Multiple compartments and lack of apocrine snouting may be a histological predictor of recurrence. All recurrent cases were treated with enucleation and/or curettage, highlighting treatment approach as a key factor.

Immunohistochemistry

Glandular odontogenic cyst

histologic features

odontogenic cysts

recurrences

Details

Title: Subtitle: Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and non-recurrent glandular odontogenic cysts - A retrospective longitudinal cohort multicenter study
Creators: Alberto Peraza-Labrador - Texas A&M Health Science Center
John Wright - Texas A&M Health Science Center
Victoria Woo - Texas A&M Health Science Center
Monica Kowalski - Columbia University
Kittiphoj Tikkhanarak - University of Iowa
Nidhi Q. Handoo - University of Iowa
Wattawan Wongpattaraworakul - Thammasat University
Elizabeth Bilodeau - Emory and Henry College
Felipe Nor - University of Michigan
Molly Housley Smith - University of Kentucky
Matthew Kesterke - Texas A&M Health Science Center
Hua Zhang - Texas A&M Health Science Center
Patricia Barros - Nova Southeastern University
Madhu Shrestha - Texas A&M Health Science Center
Resource Type: Journal article
Publication Details: Oral surgery, oral medicine, oral pathology and oral radiology, Vol.141(1), pp.86-95
DOI: 10.1016/j.oooo.2025.08.010
PMID: 40962685
NLM abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol
ISSN: 2212-4403
eISSN: 2212-4411
Publisher: Elsevier Inc
Grant note: Texas A&M University graduate student thesis fund (APL) and start-up funds (MS)
This study was funded by the Texas A&M University graduate student thesis fund (APL) and start-up funds (MS) .
Language: English
Electronic publication date: 08/2025
Date published: 01/2026
Academic Unit: Oral Pathology, Radiology and Medicine
Record Identifier: 9984949522602771

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