Journal article
Comparing Kidney Perfusion Using Noncontrast Arterial Spin Labeling MRI and Microsphere Methods in an Interventional Swine Model
Investigative radiology, Vol.46(2), pp.124-131
02/01/2011
DOI: 10.1097/RLI.0b013e3181f5e101
PMCID: PMC3368348
PMID: 22609830
Abstract
Objective: The purpose of this study was to assess the ability of a flow-sensitive alternating inversion recovery-arterial spin labeling (FAIR-ASL) technique to track renal perfusion changes during pharmacologic and physiologic alterations in renal blood flow using microspheres as a gold standard.
Materials and Methods: Fluorescent microsphere and FAIR-ASL perfusion were compared in the cortex of the kidney for 11 swine across 4 interventional time points: (1) under baseline conditions, (2) during an acetylcholine and fluid bolus challenge to increase perfusion, (3) initially after switching to isoflurane anesthesia, and (4) after 2 hours of isoflurane anesthesia. In 10 of the 11 swine, a bag of ice was placed on the hilum of 1 kidney at the beginning of isoflurane administration to further reduce perfusion in 1 kidney.
Results: Both ASL and microspheres tracked the expected cortical perfusion changes (P < 0.02) across the interventions, including an increase in perfusion during the acetylcholine challenge and decrease during the administration of isoflurane. Both techniques also measured lower cortical perfusion in the iced compared with the noniced kidneys (P <= 0.01). The ASL values were systematically lower compared with microsphere perfusion. Very good correlation (r = 0.81, P < 0.0001) was observed between the techniques, and the relationship appeared linear for perfusion values in the expected physiologic range (microsphere perfusion < 550 mL/min/100 g) although ASL values saturated for perfusion >550 mL/min/100 g.
Conclusion: Cortical perfusion measured with ASL correlated with microspheres and reliably detected changes in renal perfusion in response to physiologic challenge.
Details
- Title: Subtitle
- Comparing Kidney Perfusion Using Noncontrast Arterial Spin Labeling MRI and Microsphere Methods in an Interventional Swine Model
- Creators
- Nathan S. Artz - University of Wisconsin–MadisonAndrew L. Wentland - Univ Wisconsin, Dept Med Phys, Wisconsin Inst Med Res, Madison, WI 53705 USAElizabeth A. Sadowski - Univ Wisconsin, Dept Radiol, Wisconsin Inst Med Res, Madison, WI 53705 USAArjang Djamali - Univ Wisconsin, Dept Nephrol, Wisconsin Inst Med Res, Madison, WI 53705 USAThomas M. Grist - Univ Wisconsin, Dept Med Phys, Wisconsin Inst Med Res, Madison, WI 53705 USASongwon Seo - University of Wisconsin–MadisonSean B. Fain - Univ Wisconsin, Dept Med Phys, Wisconsin Inst Med Res, Madison, WI 53705 USA
- Resource Type
- Journal article
- Publication Details
- Investigative radiology, Vol.46(2), pp.124-131
- DOI
- 10.1097/RLI.0b013e3181f5e101
- PMID
- 22609830
- PMCID
- PMC3368348
- NLM abbreviation
- Invest Radiol
- ISSN
- 0020-9996
- eISSN
- 1536-0210
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- internal department research funds R01 DK073680; R21 DK070243 / National Institute of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R21DK070243 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) GE Healthcare; General Electric Society of Uroradiology T32GM008692 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 02/01/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274954302771
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