Journal article
Comparing Risperidone and Olanzapine to Tetrabenazine for the Management of Chorea in Huntington Disease: An Analysis from the Enroll‐HD Database
Movement disorders clinical practice (Hoboken, N.J.), Vol.6(2), pp.132-138
02/2019
DOI: 10.1002/mdc3.12706
PMCID: PMC6384174
PMID: 30838312
Abstract
ABSTRACT
Introduction
Huntington's chorea (HC) is commonly managed with neuroleptic medications, though there is little evidence to support their use. This study aimed to perform a real‐world comparison of the efficacy of risperidone and olanzapine to tetrabenazine (TBZ) for HC.
Methods
The Enroll‐HD database was used to perform a propensity score‐matched comparison of risperidone and olanzapine to TBZ, regarding their efficacy in controlling chorea. Participants with motor manifest Huntington's disease (HD) were grouped according to their use of risperidone, olanzapine, or TBZ. For the three groups, independent propensity score matching was performed on participants’ baseline total functional score (TFC), baseline total motor score (TMS), disease burden score, CAG repeat length, baseline age, region, sex, and body mass index. Independent samples t test was used to calculate the differences between the groups in the annual rate of change of the TMS from the baseline to the second available visit.
Results
The risperidone (n = 72) and olanzapine groups (n = 77) had annualized increases (worsening) in the TMS of only 1.47 points and 3.20 points, respectively, compared to 5.70 points in the two matched TBZ groups (n = 72) (P = 0.019) and (n = 77) (P = 0.143), respectively.
Conclusions
In the absence of prospective data, this analysis of the Enroll‐HD database found that the neuroleptics risperidone and olanzapine seemed to at least be comparable to TBZ at controlling HC. These results demonstrate that neuroleptics may have comparable efficacy to TBZ for the treatment of HC. Further prospective studies are needed to confirm these findings.
Details
- Title: Subtitle
- Comparing Risperidone and Olanzapine to Tetrabenazine for the Management of Chorea in Huntington Disease: An Analysis from the Enroll‐HD Database
- Creators
- Jordan L Schultz - The University of Iowa Hospitals and ClinicsJohn A Kamholz - The University of Iowa Hospitals and ClinicsPeg C Nopoulos - The University of Iowa Hospitals and ClinicsAnnie Killoran - The Veteran's Affairs Medical Center
- Resource Type
- Journal article
- Publication Details
- Movement disorders clinical practice (Hoboken, N.J.), Vol.6(2), pp.132-138
- DOI
- 10.1002/mdc3.12706
- PMID
- 30838312
- PMCID
- PMC6384174
- ISSN
- 2330-1619
- eISSN
- 2330-1619
- Number of pages
- 20
- Language
- English
- Date published
- 02/2019
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Pharmacy Practice and Science
- Record Identifier
- 9984070871802771
Metrics
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