Journal article
Comparing children and adults with chronic nonbacterial osteomyelitis
Current opinion in rheumatology, Vol.32(5), pp.421-426
09/2020
DOI: 10.1097/BOR.0000000000000734
PMID: 32744822
Abstract
To describe the main clinical differences of children and adults with chronic nonbacterial osteomyelitis (CNO).
CNO is a severe systemic autoinflammatory syndrome characterized by multiple bone lesions because of inflammatory osteitis. Delay to diagnosis of CNO can lead to functional impairment, fractures, and chronic pain. Key clinical aspects and disease patterns differ in children and adults, including onset and time to diagnosis, symptom localization, associated comorbidities (i.e. skin, joints), bone lesion distribution pattern, and treatment approach. Novel biomarkers, such as urine N-terminal telopeptide in children and serum IgG4 in adults, are being studied for possible future use in improving diagnosis and guiding treatment. Despite recent advances in our understanding of CNO, many children and adults have a high disease burden and poor long-term outcomes. Recent findings suggest that adults with CNO tend to have a more chronic disease course and are less likely to achieve remission in follow-up.
The clinical presentation of CNO differs in children and adults, highlighting the importance of these key features for the accurate diagnosis and early treatment in CNO.
Details
- Title: Subtitle
- Comparing children and adults with chronic nonbacterial osteomyelitis
- Creators
- Aleksander Lenert - Division of Immunology, Department of Internal MedicinePolly J Ferguson - Division of Pediatric Rheumatology, Allergy and Immunology, Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in rheumatology, Vol.32(5), pp.421-426
- Publisher
- United States
- DOI
- 10.1097/BOR.0000000000000734
- PMID
- 32744822
- ISSN
- 1040-8711
- eISSN
- 1531-6963
- Grant note
- R01 AR059703 / NIAMS NIH HHS R01 NS098590 / NINDS NIH HHS
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology; Immunology; Internal Medicine
- Record Identifier
- 9984070326002771
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