Comparison Between Graders in Detection of Diabetic Neovascularization With Swept Source Optical Coherence Tomography Angiography and Fluorescein Angiography

Hasenin Al-Khersan; Jonathan F Russell; Thomas A Lazzarini; Nathan L Scott; John W Hinkle; Nimesh A Patel; Nicolas A Yannuzzi; Benjamin J Fowler; Rehan M Hussain; Anita Barikian; Jayanth Sridhar; Stephen R Russell; Luis J Haddock; William E Smiddy; Seenu M Hariprasad; Yingying Shi; Liang Wang; William Feuer; Giovanni Gregori; Philip J Rosenfeld

doi:10.1016/j.ajo.2020.11.020

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Comparison Between Graders in Detection of Diabetic Neovascularization With Swept Source Optical Coherence Tomography Angiography and Fluorescein Angiography

Journal article

Peer reviewed

Comparison Between Graders in Detection of Diabetic Neovascularization With Swept Source Optical Coherence Tomography Angiography and Fluorescein Angiography

Hasenin Al-Khersan, Jonathan F Russell, Thomas A Lazzarini, Nathan L Scott, John W Hinkle, Nimesh A Patel, Nicolas A Yannuzzi, Benjamin J Fowler, Rehan M Hussain, Anita Barikian, …

American journal of ophthalmology, Vol.224, pp.292-300

04/2021

DOI: 10.1016/j.ajo.2020.11.020

PMCID: PMC8058287

PMID: 33309812

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https://www.ncbi.nlm.nih.gov/pmc/articles/8058287View

Open Access

Abstract

We compared the ability of ophthalmologists to identify neovascularization (NV) in patients with proliferative diabetic retinopathy using swept-source optical coherence tomography angiography (SS-OCTA) and fluorescein angiography (FA). Retrospective study comparing diagnostic instruments. Eyes with proliferative diabetic retinopathy or severe nonproliferative diabetic retinopathy and a high suspicion of NV based on clinical examination were imaged using SS-OCTA and FA at the same visit. Two separate grading sets consisting of scrambled, anonymized SS-OCTA and FA images were created. The ground truth for presence of NV was established by consensus of 2 graders with OCTA experience who did not participate in the subsequent assessment of NV in this study. The 2 anonymized image sets were graded for presence or absence of NV by 12 other graders that included 2 residents, 6 vitreoretinal fellows, and 4 vitreoretinal attending physicians. The percentage of correct grading of NV using SS-OCTA and FA was assessed for each grader and across grader training levels. Forty-seven eyes from 24 patients were included in this study. Overall, the mean percentage of correct NV grading was 87.8% using SS-OCTA with B-scans and 86.2% using FA (P = .92). Assessing each grader individually, there was no statistically significant asymmetry in correct grading using SS-OCTA and FA. Ophthalmologists across training levels were able to identify diabetic NV with equal accuracy using SS-OCTA and FA. Based on these results, SS-OCTA may be an appropriate standalone modality for diagnosing diabetic NV.

Adult

Diabetic Retinopathy - classification

Diabetic Retinopathy - diagnosis

False Positive Reactions

Female

Fluorescein Angiography

Humans

Male

Middle Aged

Ophthalmologists - standards

Predictive Value of Tests

Reproducibility of Results

Retinal Neovascularization - classification

Retinal Neovascularization - diagnosis

Retinal Vessels - pathology

Retrospective Studies

Tomography, Optical Coherence

Visual Acuity

Details

Title: Subtitle: Comparison Between Graders in Detection of Diabetic Neovascularization With Swept Source Optical Coherence Tomography Angiography and Fluorescein Angiography
Creators: Hasenin Al-Khersan - Bascom Palmer Eye Institute, Miami, Florida, USA
Jonathan F Russell - Bascom Palmer Eye Institute
Thomas A Lazzarini - Bascom Palmer Eye Institute
Nathan L Scott - Bascom Palmer Eye Institute
John W Hinkle - Thomas Jefferson University
Nimesh A Patel - Bascom Palmer Eye Institute
Nicolas A Yannuzzi - Bascom Palmer Eye Institute
Benjamin J Fowler - Bascom Palmer Eye Institute
Rehan M Hussain - Retina Associates
Anita Barikian - Bascom Palmer Eye Institute
Jayanth Sridhar - Bascom Palmer Eye Institute
Stephen R Russell - University of Iowa
Luis J Haddock - Bascom Palmer Eye Institute
William E Smiddy - Bascom Palmer Eye Institute
Seenu M Hariprasad - University of Chicago
Yingying Shi - Bascom Palmer Eye Institute
Liang Wang - Bascom Palmer Eye Institute
William Feuer - Bascom Palmer Eye Institute
Giovanni Gregori - Bascom Palmer Eye Institute
Philip J Rosenfeld - Bascom Palmer Eye Institute
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.224, pp.292-300
DOI: 10.1016/j.ajo.2020.11.020
PMID: 33309812
PMCID: PMC8058287
NLM abbreviation: Am J Ophthalmol
ISSN: 0002-9394
eISSN: 1879-1891
Grant note: P30 EY014801 / NEI NIH HHS
Language: English
Date published: 04/2021
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984186927102771

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