Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene

Victor Kim; James Crapo; Huaqing Zhao; Paul W Jones; Edwin K Silverman; Alejandro Comellas; Barry J Make; Gerard J Criner; COPDGene Investigators

doi:10.1513/AnnalsATS.201411-518OC

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Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene

Journal article

Open access

Peer reviewed

Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene

Victor Kim, James Crapo, Huaqing Zhao, Paul W Jones, Edwin K Silverman, Alejandro Comellas, Barry J Make, Gerard J Criner and COPDGene Investigators

Annals of the American Thoracic Society, Vol.12(3), pp.332-339

03/2015

DOI: 10.1513/AnnalsATS.201411-518OC

PMCID: PMC4418311

PMID: 25575351

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Abstract

Previous studies on chronic bronchitis (CB) have used varying definitions. We sought to compare an alternative CB definition, using the St. George's Respiratory Questionnaire (SGRQ), a commonly used assessment tool, with the classic definition and to investigate if it had independent or additive value. We analyzed data from 4,513 subjects from Global Initiative for Chronic Obstructive Lung Disease groups 1 to 4 in the COPDGene cohort. We compared the classic definition of CB with the SGRQ definition, defined by their answers to the questions about both cough and phlegm. We compared the Classic CB+ versus CB- groups, and the SGRQ CB+ and CB- groups. We also analyzed the cohort split into four groups: Classic CB+/SGRQ CB+, Classic CB+/SGRQ CB-, Classic CB-/SGRQ CB+, Classic CB-/SGRQ CB-. A total of 26.1% subjects were Classic CB+, whereas 39.9% were SGRQ CB+. When the SGRQ definition was compared with the Classic CB definition, using this as the gold standard, the SGRQ CB definition had a sensitivity and specificity of 0.87 and 0.77, respectively. The SGRQ CB+ and Classic CB+ groups were strikingly similar, with more respiratory symptoms and exacerbations, worse lung function, and greater airway wall thickness. In addition, the Classic CB+/SGRQ CB+, Classic CB+/SGRQ CB-, and Classic CB-/SGRQ CB+ groups shared similar characteristics as well. The SGRQ CB definition identifies more subjects with chronic cough and sputum who share a similar phenotype identified by the Classic CB definition. The addition of the SGRQ CB definition to the classic one can be used to identify more patients with chronic obstructive pulmonary disease at risk for poor outcomes.

Severity of Illness Index

Pulmonary Disease, Chronic Obstructive - diagnosis

Spirometry

Humans

Middle Aged

Pulmonary Disease, Chronic Obstructive - classification

Male

Bronchitis, Chronic - diagnosis

Pulmonary Disease, Chronic Obstructive - physiopathology

Bronchitis, Chronic - physiopathology

Bronchitis, Chronic - complications

Quality of Life

Adult

Female

Aged

Radiography, Thoracic

Details

Title: Subtitle: Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene
Creators: Victor Kim - 1 Department of Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania
James Crapo
Huaqing Zhao
Paul W Jones
Edwin K Silverman
Alejandro Comellas
Barry J Make
Gerard J Criner
COPDGene Investigators
Resource Type: Journal article
Publication Details: Annals of the American Thoracic Society, Vol.12(3), pp.332-339
DOI: 10.1513/AnnalsATS.201411-518OC
PMID: 25575351
PMCID: PMC4418311
NLM abbreviation: Ann Am Thorac Soc
ISSN: 2325-6621
eISSN: 2325-6621
Publisher: American Thoracic Society
Grant note: R01 HL089897 / NHLBI NIH HHS U01 HL089897 / NHLBI NIH HHS R01 HL089856 / NHLBI NIH HHS K23HL094696 / NHLBI NIH HHS K23 HL094696 / NHLBI NIH HHS
Language: English
Date published: 03/2015
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
Record Identifier: 9984094560902771

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