Journal article
Comparison of 2D fiber network orientation measurement methods
Journal of biomedical materials research. Part A, Vol.88(2), pp.322-331
02/2009
DOI: 10.1002/jbm.a.31847
PMID: 18286605
Abstract
The mechanical properties of tissues, tissue analogs, and biomaterials are dependent on their underlying microstructure. As such, many mechanical models incorporate some aspect of microstructure, but a robust protocol for characterizing fiber architecture remains a challenge. A number of image-based methods, including mean intercept length (MIL), line fraction deviation (LFD), and Fourier transform methods (FTM), have been applied to microstructural images to describe material heterogeneity and orientation, but a performance comparison, particularly for fiber networks, has not been conducted. In this study, we constructed 40 two-dimensional test images composed of simulated fiber networks varying in fiber number, orientation, and anisotropy index. We assessed the accuracy of each method in measuring principal direction (theta) and anisotropy index (alpha). FTM proved to be the superior method because it was more reliable in measurement accuracy (Deltatheta = 2.95 degrees +/- 6.72 degrees , Deltaalpha = 0.03 +/- 0.02), faster in execution time, and flexible in its application. MIL (Deltatheta = 6.23 degrees +/- 10.68 degrees , Deltaalpha = 0.08 +/- 0.06) was not significantly less accurate than FTM but was much slower. LFD (Deltatheta = 9.97 degrees +/- 11.82 degrees , Deltaalpha = 0.24 +/- 0.13) consistently underperformed. FTM results agreed qualitatively with fibrin gel SEM micrographs, suggesting that FTM can be used to obtain image-based statistical measurements of microstructure.
Details
- Title: Subtitle
- Comparison of 2D fiber network orientation measurement methods
- Creators
- E A Sander - Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USAV H Barocas
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research. Part A, Vol.88(2), pp.322-331
- DOI
- 10.1002/jbm.a.31847
- PMID
- 18286605
- NLM abbreviation
- J Biomed Mater Res A
- ISSN
- 1549-3296
- eISSN
- 1552-4965
- Publisher
- United States
- Grant note
- 1 R01 EB005813-01 / NIBIB NIH HHS
- Language
- English
- Date published
- 02/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
- Record Identifier
- 9984064569802771
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