Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis

Paulo Henrique Rosado-de-Castro; Thiago Pereira-de-Carvalho; Miriam Menna Barreto; Afranio Lineu Kritski; Rebecca de Oliveira Souza; Sergio Altino de Almeida; Valeria Cavalcanti Rolla; Walter Araujo Zin; Alysson Roncally Silva Carvalho; Rosana Souza Rodrigues

doi:10.4269/ajtmh.21-0416

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Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis

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Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis

Paulo Henrique Rosado-de-Castro, Thiago Pereira-de-Carvalho, Miriam Menna Barreto, Afranio Lineu Kritski, Rebecca de Oliveira Souza, Sergio Altino de Almeida, Valeria Cavalcanti Rolla, Walter Araujo Zin, Alysson Roncally Silva Carvalho and Rosana Souza Rodrigues

The American journal of tropical medicine and hygiene, Vol.106(5), pp.1340-1344

04/04/2022

DOI: 10.4269/ajtmh.21-0416

PMID: 35378506

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Abstract

Tuberculosis (TB) remains one of the world's leading infectious cause of morbidity and mortality. Positron emission tomography (PET) associated with computed tomography (CT) allows a structural and metabolic evaluation of TB lesions, being an excellent noninvasive alternative for understanding its pathogenesis. DOTATOC labeled with gallium-68 (Ga-68-DOTATOC) can bind to somatostatin receptors present in activated macrophages and lymphocytes, cells with a fundamental role in TB pathogenesis. We describe Ga-68-DOTATOC uptake distribution and patterns in thoracic lymph nodes (LN) and pulmonary lesions (PL) in immunocompetent patients with active postprimary TB, analyze the relative LN/PL uptake, and compare this two tracer's uptake. High uptake of both radiotracers in PL and LN was demonstrated, with higher LN/PL ratio on Ga-68-DOTATOC (P < 0.05). Considering that LN in immunocompetent patients are poorly studied, Ga-68-DOTATOC can contribute to the understanding of the complex immunopathogenesis of TB.

Life Sciences & Biomedicine

Public, Environmental & Occupational Health

Science & Technology

Tropical Medicine

Details

Title: Subtitle: Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis
Creators: Paulo Henrique Rosado-de-Castro - D’Or Institute for Research and Education
Thiago Pereira-de-Carvalho - Faculdade de Medicina de Petrópolis
Miriam Menna Barreto - Universidade Federal do Rio de Janeiro
Afranio Lineu Kritski - Universidade Federal do Rio de Janeiro
Rebecca de Oliveira Souza - Univ Fed Rio de Janeiro, Dept Stat Methods, Rio De Janeiro, Brazil
Sergio Altino de Almeida - D’Or Institute for Research and Education
Valeria Cavalcanti Rolla - ms consultants, inc.
Walter Araujo Zin - Universidade Federal do Rio de Janeiro
Alysson Roncally Silva Carvalho - Univ Fed Rio de Janeiro, Carlos Chagas Filho Inst Biophys, Lab Respirat Physiol, Rio De Janeiro, Brazil
Rosana Souza Rodrigues - D’Or Institute for Research and Education
Resource Type: Journal article
Publication Details: The American journal of tropical medicine and hygiene, Vol.106(5), pp.1340-1344
DOI: 10.4269/ajtmh.21-0416
PMID: 35378506
NLM abbreviation: Am J Trop Med Hyg
ISSN: 0002-9637
eISSN: 1476-1645
Publisher: Amer Soc Trop Med & Hygiene
Number of pages: 5
Grant note: 302839/2017-8; 312410/2017-4 / Brazilian National Council for Scientific and Technological Development (CNPq); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) E-26/202.751/2018; E-26/203.001/2018; E-26/203.279/2017; E-26/211.867/2016 / Carlos Chagas Filho Research Support Foundation of the State of Rio de Janeiro (FAPERJ); Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ)
Language: English
Date published: 04/04/2022
Academic Unit: Radiology
Record Identifier: 9985143125602771

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