Comparison of Cancer Diagnoses Between the US Solid Organ Transplant Registry and Linked Central Cancer Registries

E L Yanik; L M Nogueira; L Koch; G Copeland; C F Lynch; K S Pawlish; J L Finch; A R Kahn; B Y Hernandez; D L Segev; R M Pfeiffer; J J Snyder; B L Kasiske; E A Engels

doi:10.1111/ajt.13818

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Comparison of Cancer Diagnoses Between the US Solid Organ Transplant Registry and Linked Central Cancer Registries

Journal article

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Comparison of Cancer Diagnoses Between the US Solid Organ Transplant Registry and Linked Central Cancer Registries

E L Yanik, L M Nogueira, L Koch, G Copeland, C F Lynch, K S Pawlish, J L Finch, A R Kahn, B Y Hernandez, D L Segev, …

American journal of transplantation, Vol.16(10), pp.2986-2993

10/2016

DOI: 10.1111/ajt.13818

PMCID: PMC5055411

PMID: 27062091

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Abstract

US transplant centers are required to report cancers in transplant recipients to the transplant network. The accuracy and completeness of these data, collected in the Scientific Registry of Transplant Recipients (SRTR), are unknown. We compared diagnoses in the SRTR and 15 linked cancer registries for colorectal, liver, lung, breast, prostate and kidney cancers; melanoma; and non-Hodgkin lymphoma (NHL). Among 187 384 transplants, 9323 cancers were documented in the SRTR or cancer registries. Only 36.8% of cancers were in both, with 47.5% and 15.7% of cases additionally documented solely in cancer registries or the SRTR, respectively. Agreement between the SRTR and cancer registries varied (kappa = 0.28 for liver cancer and kappa = 0.52-0.66 for lung, prostate, kidney, colorectum, and breast cancers). Upon evaluation, some NHLs documented only in cancer registries were identified in the SRTR as another type of posttransplant lymphoproliferative disorder. Some SRTR-only cases were explained by miscoding (colorectal cancer instead of anal cancer, metastases as lung or liver cancers) or missed matches with cancer registries, partly due to recipients' outmigration from catchment areas. Estimated sensitivity for identifying cancer was 52.5% for the SRTR and 84.3% for cancer registries. In conclusion, SRTR cancer data are substantially incomplete, limiting their usefulness for surveillance and research.

United States - epidemiology

Prognosis

Data Collection - standards

Registries - standards

Humans

Adult

Female

Male

Organ Transplantation

Neoplasms - diagnosis

Neoplasms - epidemiology

Incidence

Details

Title: Subtitle: Comparison of Cancer Diagnoses Between the US Solid Organ Transplant Registry and Linked Central Cancer Registries
Creators: E L Yanik - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
L M Nogueira - Texas Cancer Registry, Texas Department of State Health Services, Austin, TX
L Koch - Illinois State Cancer Registry, Illinois Department of Public Health, Springfield, IL
G Copeland - Michigan Cancer Surveillance Program, Michigan Department of Health and Human Services, Lansing, MI
C F Lynch - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA
K S Pawlish - New Jersey State Cancer Registry, Cancer Epidemiology Services, New Jersey Department of Health, Trenton, NJ
J L Finch - Colorado Central Cancer Registry, Colorado Department of Public Health and Environment, Denver, CO
A R Kahn - New York State Cancer Registry, New York State Department of Health, Albany, NY
B Y Hernandez - University of Hawaii Cancer Center, Honolulu, HI
D L Segev - Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD
R M Pfeiffer - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
J J Snyder - Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN
B L Kasiske - Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN
E A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
Resource Type: Journal article
Publication Details: American journal of transplantation, Vol.16(10), pp.2986-2993
DOI: 10.1111/ajt.13818
PMID: 27062091
PMCID: PMC5055411
NLM abbreviation: Am J Transplant
ISSN: 1600-6143
eISSN: 1600-6143
Publisher: United States
Grant note: N01PC35142 / NCI NIH HHS HHSN261201000024C / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS U58 DP003875 / NCCDPHP CDC HHS Z01 CP010150-09 / Intramural NIH HHS U58 DP003931 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS U58 DP003921 / NCCDPHP CDC HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS U58 DP003879 / NCCDPHP CDC HHS HHSN261201300011C / CCR NIH HHS HHSN261201300071C / NCI NIH HHS U58 DP003920 / NCCDPHP CDC HHS U58 DP000848 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS HHSN261201300021C / NCI NIH HHS HHSN261201300011I / NCI NIH HHS HHSN261201000037C / NCI NIH HHS N01PC35143 / NCI NIH HHS U58 DP003883 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
Language: English
Date published: 10/2016
Academic Unit: Epidemiology
Record Identifier: 9983995106602771

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