Journal article
Comparison of Cytomegalovirus Loads in Plasma and Leukocytes of Patients with Cytomegalovirus Retinitis
Journal of clinical microbiology, Vol.37(5), pp.1431-1435
05/1999
DOI: 10.1128/JCM.37.5.1431-1435.1999
PMCID: PMC84793
PMID: 10203500
Abstract
Cytomegalovirus (CMV) DNA loads in paired leukocyte and plasma samples from 199 patient visits by 66 patients with CMV retinitis were determined. Leukocyte CMV load determinations had a greater range of values (mean, 24,587 copies/10
6
leukocytes; maximum, 539,000) than did plasma CMV load determinations (mean, 10,302 copies/ml; maximum, 386,000), and leukocyte viral loads were detectable in a greater proportion of patients at the time of diagnosis of CMV retinitis prior to initiation of anti-CMV therapy (82%) than were plasma viral loads (64%) (
P
= 0.0078). Agreement with CMV blood cultures was slightly better for plasma (κ = 0.68) than for leukocytes (κ = 0.53), due to a greater proportion of patients with detectable viral loads in leukocytes having negative blood cultures.
Details
- Title: Subtitle
- Comparison of Cytomegalovirus Loads in Plasma and Leukocytes of Patients with Cytomegalovirus Retinitis
- Creators
- Douglas A Jabs - Departments of OphthalmologyMichael Forman - Departments of OphthalmologyCheryl Enger - Departments of OphthalmologyJ. Brooks Jackson - Departments of Ophthalmology
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.37(5), pp.1431-1435
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/JCM.37.5.1431-1435.1999
- PMID
- 10203500
- PMCID
- PMC84793
- ISSN
- 0095-1137
- eISSN
- 1098-660X
- Language
- English
- Date published
- 05/1999
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047723302771
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