Journal article
Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones
Antimicrobial agents and chemotherapy, Vol.54(7), pp.3011-3014
07/2010
DOI: 10.1128/AAC.00190-10
PMCID: PMC2897325
PMID: 20404126
Abstract
Bacterial resistance presents a difficult issue for fluoroquinolone treatment of bacterial infections. In previous work, we reported that 8-methoxy-quinazoline-2,4-diones are active against quinolone-resistant mutants of Escherichia coli. Here, we demonstrate the activity of a representative 8-methoxy-quinazoline-2,4-dione against quinolone-resistant gyrases. Furthermore, 8-methoxy-quinazoline-2,4-dione and other diones are shown to inhibit Staphylococcus aureus gyrase and topoisomerase IV with similar degrees of efficacy, suggesting that the diones might act as dual-targeting agents against S. aureus.
Details
- Title: Subtitle
- Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones
- Creators
- Lisa M Oppegard - University of MinnesotaKathryn R Streck - University of MinnesotaJonathan D Rosen - University of IowaHeidi A Schwanz - University of IowaKarl Drlica - Rutgers, The State University of New JerseyRobert J Kerns - University of IowaHiroshi Hiasa - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.54(7), pp.3011-3014
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/AAC.00190-10
- PMID
- 20404126
- PMCID
- PMC2897325
- ISSN
- 0066-4804
- eISSN
- 1098-6596
- Language
- English
- Date published
- 07/2010
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984365879702771
Metrics
1 Record Views