Journal article
Comparison of Left Anterior Descending Coronary Artery Hemodynamics Before and After Angioplasty
Journal of biomechanical engineering, Vol.128(1), pp.40-48
02/01/2006
DOI: 10.1115/1.2132371
PMID: 16532616
Abstract
Coronary artery disease (CAD) is characterized by the progression of atherosclerosis, a complex pathological process involving the initiation, deposition, development, and breakdown of the plaque. The blood flow mechanics in arteries play a critical role in the targeted locations and progression of atherosclerotic plaque. In coronary arteries with motion during the cardiac contraction and relaxation, the hemodynamic flow field is substantially different from the other arterial sites with predilection of atherosclerosis. In this study, our efforts focused on the effects of arterial motion and local geometry on the hemodynamics of a left anterior descending (LAD) coronary artery before and after clinical intervention to treat the disease. Three-dimensional (3D) arterial segments were reconstructed at 10 phases of the cardiac cycle for both pre- and postintervention based on the fusion of intravascular ultrasound (IVUS) and biplane angiographic images. An arbitrary Lagrangian-Eulerian formulation was used for the computational fluid dynamic analysis. The measured arterial translation was observed to be larger during systole after intervention and more out-of-plane motion was observed before intervention, indicating substantial alterations in the cardiac contraction after angioplasty. The time averaged axial wall shear stress ranged from −0.2to9.5Pa before intervention compared to −0.02to3.53Pa after intervention. Substantial oscillatory shear stress was present in the preintervention flow dynamics compared to that in the postintervention case.
Details
- Title: Subtitle
- Comparison of Left Anterior Descending Coronary Artery Hemodynamics Before and After Angioplasty
- Creators
- S. D Ramaswamy - Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242S. C Vigmostad - Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242A Wahle - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa 52242Y.-G Lai - IIHR-Hydroscience and Engineering, University of Iowa, Iowa City, Iowa 52242M. E Olszewski - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa 52242K. C Braddy - Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242T. M. H Brennan - Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242J. D Rossen - Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242M Sonka - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa 52242K. B Chandran - Department of Biomedical Engineering and IIHR-Hydroscience and Engineering, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Journal of biomechanical engineering, Vol.128(1), pp.40-48
- DOI
- 10.1115/1.2132371
- PMID
- 16532616
- NLM abbreviation
- J Biomech Eng
- ISSN
- 0148-0731
- eISSN
- 1528-8951
- Publisher
- ASME
- Language
- English
- Date published
- 02/01/2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Electrical and Computer Engineering; Cardiovascular Medicine; Surgery; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Neurosurgery; Mechanical Engineering; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984047603702771
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