Journal article
Comparison of PET/MRI With PET/CT in the Evaluation of Disease Status in Lymphoma
Clinical nuclear medicine, Vol.42(1), pp.E1-E7
01/01/2017
DOI: 10.1097/RLU.0000000000001344
PMCID: PMC5538384
PMID: 27607161
Abstract
Purpose: The primary aim was to compare the diagnostic performance of PET/MRI (performed with basic anatomical MRI sequences) in detecting sites of disease in adult patients with lymphoma compared with the current standard of care, PET/CT. Secondary aims were to assess the additional value of diffusion-weighted imaging to PET/MRI in disease detection and to evaluate the relationship between the standardized uptake value on PET/MR and the apparent diffusion coefficient on diffusion-weighted imaging.
Methods: Sixty-eight studies in 66 consecutive patients with histologically proven Hodgkin or non-Hodgkin lymphoma were prospectively evaluated. Each patient had whole body PET/CT, followed by whole body PET/MR. Two experienced readers independently evaluated the PET/MRI studies, and two other experienced readers independently evaluated PET/CT. Site of lymphoma involvement and SUVmax at all nodal sites more avid than background liver were recorded. Readers provided stage (in baseline cases) and disease status (remission vs active disease). The apparent diffusion coefficient mean value corresponding to the most avid PET site of disease was recorded.
Results: Ninety-five nodal and 8 extranodal sites were identified on both PET/CT and PET/MRI. In addition, 3 nodal and 1 extranodal sites were identified on PET/MRI. For positive lesion detection, reader agreement in PET/MR was perfect between the 2 readers and almost perfect between PET/CT and PET/MR (k > 0.978). Intermodality agreement between PET/CT and PET/MRI was also near perfect to perfect for staging/disease status k = (0.979-1.000). SUVmax from PET/CT and PET/MRI correlated significantly (Spearman rho correlation coefficient, 0.842; P < 0.001). Diffusion-weighted imaging did not alter lesion detection or staging in any case. A negative correlation was demonstrated between ADC mean and SUVmax (Spearman rho correlation coefficient r, -0.642; P < 0.001).
Conclusions: PET/MRI is a reliable alternative to PET/CT in the evaluation of patients with lymphoma. Diffusion-weighted imaging did not alter diagnostic accuracy. With comparable accuracy in detection of disease sites and added benefit of radiation dose reduction, PET/MRI has a potential to become part of routine lymphoma imaging.
Details
- Title: Subtitle
- Comparison of PET/MRI With PET/CT in the Evaluation of Disease Status in Lymphoma
- Creators
- Asim Afaq - University College London Hospitals NHS Foundation TrustFrancesco Fraioli - University College LondonHarbir Sidhu - Chang Gung Memorial HospitalSimon Wan - Memorial Sloan Kettering Cancer CenterShonit Punwani - UCL Cancer institute, University College London, London, UK.Shih-hsin Chen - University College London Hospitals NHS Foundation TrustOguz Akin - Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10021 USADavid Linch - UCL, UCL Canc Inst, London, EnglandKirit Ardeshna - Univ Coll London Hosp NHS Fdn Trust, Dept Clin Haematol, London, EnglandJonathan Lambert - Univ Coll London Hosp NHS Fdn Trust, Dept Clin Haematol, London, EnglandKenneth Miles - UCL, Inst Nucl Med, London, EnglandAshley Groves - UCL, Inst Nucl Med, London, EnglandIrfan Kayani - UCL, Inst Nucl Med, London, England
- Resource Type
- Journal article
- Publication Details
- Clinical nuclear medicine, Vol.42(1), pp.E1-E7
- DOI
- 10.1097/RLU.0000000000001344
- PMID
- 27607161
- PMCID
- PMC5538384
- NLM abbreviation
- Clin Nucl Med
- ISSN
- 0363-9762
- eISSN
- 1536-0229
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- UCL Experimental Cancer Medicine Centre National Institute for Health Research University College London Hospitals Biomedical Research Centre; General Electric P30CA008748 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 01/01/2017
- Academic Unit
- Radiology
- Record Identifier
- 9984318697002771
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