Journal article
Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study
Alcoholism, clinical and experimental research, Vol.41(2), pp.359-368
02/2017
DOI: 10.1111/acer.13293
PMCID: PMC5272776
PMID: 28073157
Abstract
All stages of development of alcohol use disorder (AUD) have not been equally studied. While initiation of drinking has been given considerable attention, other stages have not been as thoroughly investigated. It is not clear whether the same factors are associated consistently across early and late transitions in AUD involvement. High-risk family samples that are enriched for AUD vulnerability and transitions in AUD development offer an opportunity to examine influences across multiple stages of AUD development.
Data from adolescents and young adults from high-risk families were used to study 4 transitions in AUD development-time to first drink, first drink to first problem, first drink to first diagnosis, and first problem to first diagnosis. Cox modeling was used to compare associations of parental AUD, parental separation, peer substance use, offspring ever-use of cannabis, trauma exposures, and internalizing and externalizing psychopathology across transitions.
Hazards of most transitions were elevated for those who had ever used cannabis, those who attributed substance use to their peers, those with externalizing disorders, and those with parents with AUD. Many risk factors were linked to early initiation of alcohol, particularly cannabis use. Internalizing disorders were associated with later stages. Nonassaultive trauma was associated only with early initiation; assaultive trauma was not associated with any transition.
In this large, ethnically diverse sample of high-risk youth, significant influences across transitions were fairly consistent, with externalizing disorders and cannabis ever-use elevating the likelihood of each stage, and peer and parental (and especially maternal AUD) influences linked to initiation and some later stages. Finally, in light of the increasingly permissive legal and social stances toward cannabis in the United States, the marked elevations of all alcohol outcomes observed for cannabis use underscore the importance of studying the underpinnings of this relationship.
Details
- Title: Subtitle
- Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study
- Creators
- Kathleen K Bucholz - Washington University in St. LouisVivia V McCutcheon - Washington University in St. LouisArpana Agrawal - Washington University in St. LouisDanielle M Dick - Virginia Commonwealth UniversityVictor M Hesselbrock - University of ConnecticutJohn R Kramer - University of IowaSamuel Kuperman - University of IowaJohn I Nurnberger Jr - Indiana UniversityJessica E Salvatore - Virginia Commonwealth UniversityMarc A Schuckit - University of California San DiegoLaura J Bierut - Washington University in St. LouisTatiana M Foroud - Indiana UniversityGrace Chan - University of ConnecticutMichie Hesselbrock - University of ConnecticutJacquelyn L Meyers - SUNY Downstate Health Sciences UniversityHoward J Edenberg - Indiana UniversityBernice Porjesz - SUNY Downstate Health Sciences University
- Resource Type
- Journal article
- Publication Details
- Alcoholism, clinical and experimental research, Vol.41(2), pp.359-368
- DOI
- 10.1111/acer.13293
- PMID
- 28073157
- PMCID
- PMC5272776
- NLM abbreviation
- Alcohol Clin Exp Res
- ISSN
- 0145-6008
- eISSN
- 1530-0277
- Publisher
- Wiley
- Grant note
- R21 AA021235 / NIAAA NIH HHS K01 AA024152 / NIAAA NIH HHS K02 AA018755 / NIAAA NIH HHS K01 DA037914 / NIDA NIH HHS F32 AA022269 / NIAAA NIH HHS U10 AA008401 / NIAAA NIH HHS K02 DA032573 / NIDA NIH HHS
- Language
- English
- Date published
- 02/2017
- Academic Unit
- Psychiatry
- Record Identifier
- 9984293756702771
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