Journal article
Comparison of Two Specialized Histology Needles for Endoscopic Ultrasound (EUS)-Guided Liver Biopsy: A Pilot Study
Digestive diseases and sciences, Vol.66(5), pp.1700-1706
05/01/2021
DOI: 10.1007/s10620-020-06391-3
PMID: 32556821
Abstract
Background EUS-guided liver biopsy (EUS-LB) has been shown to be a safe and effective alternative to percutaneous liver biopsy. The optimal needle device and technique for EUS-LB is still evolving. The aim of this study was to compare the efficacy of two second-generation 19G fine-needle biopsy (FNB) (Franseen- and Fork-tip) devices for EUS-LB. Methods This is a repeated-measure crossover study with a prospectively maintained cohort of patients. We performed EUS-LB with a one-pass and single-actuation method using two 19G FNB needles in 22 consecutive patients between 10/2018 and 9/2019. Patients were randomized to left vs right liver lobes to be biopsied as well as the needle sequence. The specimens obtained were evaluated for adequacy for histologic diagnosis. The primary outcome was number of complete portal tracts (CPTs), post-fix aggregate, and longest specimen length. Secondary outcomes were prefix aggregate specimen length and the specimen adequacy judged by two expert pathologists. Results A total of 44 liver biopsies were performed in 22 patients. The CPTs were higher in the Franseen-tip needle group compared to the Fork-tip needle group (14.4 vs 9.5,p = 0.043). Post-fix aggregate specimen length (44.9 mm vs 34.6 mm,p = 0.097), the post-fix longest specimen length (19.9 mm vs 13.7 mm,p = 0.175), and prefix aggregate specimen length (51.7 mm vs 45 mm,p = 0.265) were not significantly different. Both needles showed similarly high histologic adequacy (100% vs 95.5%,p = 0.312). Interestingly, the right of the liver showed higher yield of CPTs with both needles (Franseen, 16.2 vs. 12.8,p= 0.003, the Fork-tip, 12.8 vs. 7.0,p< 0.0001). Conclusion EUS-guided liver biopsy using the 19G Franseen-tip needle may provide more CPTs than 19G Fork-tip needle on a single-pass, single-actuation comparison.
Details
- Title: Subtitle
- Comparison of Two Specialized Histology Needles for Endoscopic Ultrasound (EUS)-Guided Liver Biopsy: A Pilot Study
- Creators
- Rintaro Hashimoto - University of California, Irvine Medical CenterDavid P. Lee - University of California, Irvine Medical CenterJason B. Samarasena - University of California, Irvine Medical CenterVishal S. Chandan - University of California, Irvine Medical CenterWenchang Guo - University of California, Irvine Medical CenterJohn G. Lee - University of California, Irvine Medical CenterKenneth J. Chang - University of California, Irvine Medical Center
- Resource Type
- Journal article
- Publication Details
- Digestive diseases and sciences, Vol.66(5), pp.1700-1706
- Publisher
- Springer Nature
- DOI
- 10.1007/s10620-020-06391-3
- PMID
- 32556821
- ISSN
- 0163-2116
- eISSN
- 1573-2568
- Number of pages
- 7
- Language
- English
- Date published
- 05/01/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695682802771
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