Journal article
Comparison of a Neural Network Approach with Five Traditional Methods for Predicting Creatinine Clearance in Patients with Human Immunodeficiency Virus Infection
Pharmacotherapy, Vol.19(6), pp.734-740
Manuscript received October 15, 1998; Accepted for publication in final form March 4, 1999
06/1999
DOI: 10.1592/phco.19.9.734.31545
PMID: 10391419
Abstract
Study Objective. To compare the results of an artificial neural network approach with those of five published creatinine clearance (Clcr) prediction equations and with the measured (true) Clcr in patients infected with the human immunodeficiency virus (HIV).
Design. Six-month prospective study.
Settings. Two university medical centers.
Patients. Sixty-five HIV-infected patients: 18 relatively healthy outpatients and 47 inpatients.
Interventions. All subjects had urine collected for 24 hours to determine Clcr.
Measurements and Main Results. The 16 input variables were age, ideal body weight, actual body weight, body surface area, height, and the following blood chemistries: sodium, potassium, aspartate aminotransferase, alanine aminotransferase, red blood cell count, platelet count, white blood cell count, glucose, serum creatinine, blood urea nitrogen, and albumin. The only output variable was Clcr. A training set of 55 subjects was used to develop the relationship between input variables and the output variable. The trained neural network was then used to predict Clcr of a validation set of 10 subjects. Mean differences between predicted Clcr and actual Clcr (bias) were 4.1, 28.7, 29.4, 26.0, 31.8, and 55.8 ml/min/1.73 m2 for the artificial neural network, Cockcroft and Gault, Jelliffe 1, Jelliffe 2, Mawer et al, and Hull et al methods, respectively.
Conclusion. The accuracy of predicting Clcr in subjects with HIV infection by the artificial neural network is superior to that of the five equations that are currently used in clinical settings.
Details
- Title: Subtitle
- Comparison of a Neural Network Approach with Five Traditional Methods for Predicting Creatinine Clearance in Patients with Human Immunodeficiency Virus Infection
- Creators
- Ronald A Herman - College of Pharmacy, University of Iowa, Iowa City, IowaSaleem Noormohamed - College of Pharmacy, University of Iowa, Iowa City, IowaSarapee Hirankarn - College of Pharmacy, University of Iowa, Iowa City, IowaMark J Shelton - the Laboratory for Antiviral Research, Departments of Pharmacy Practice, State University of New York at Buffalo, Buffalo, New YorkEric Huang - the Laboratory for Antiviral Research, Departments of Pharmacy Practice, State University of New York at Buffalo, Buffalo, New YorkGene D Morse - the Laboratory for Antiviral Research, Departments of Pharmacy Practice, State University of New York at Buffalo, Buffalo, New YorkRoss G Hewitt - Medicine, State University of New York at Buffalo, Buffalo, New YorkJack T Stapleton - Iowa City VA Medical Center and Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Pharmacotherapy, Vol.19(6), pp.734-740
- Edition
- Manuscript received October 15, 1998; Accepted for publication in final form March 4, 1999
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1592/phco.19.9.734.31545
- PMID
- 10391419
- ISSN
- 0277-0008
- eISSN
- 1875-9114
- Number of pages
- 7
- Language
- English
- Date published
- 06/1999
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Pharmacy Practice and Science; Internal Medicine
- Record Identifier
- 9984094495602771
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