Comparison of airway diameter measurements from an anthropomorphic airway tree phantom using hyperpolarized 3He MRI and high-resolution computed tomography

Yang-Sheng Tzeng; Eric Hoffman; Janice Cook-Granroth; Rie Maurer; Niral Shah; Joey Mansour; Juerg Tschirren; Mitchell Albert

doi:10.1002/mrm.21285

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Comparison of airway diameter measurements from an anthropomorphic airway tree phantom using hyperpolarized 3He MRI and high-resolution computed tomography

Journal article

Open access

Peer reviewed

Comparison of airway diameter measurements from an anthropomorphic airway tree phantom using hyperpolarized 3He MRI and high-resolution computed tomography

Yang-Sheng Tzeng, Eric Hoffman, Janice Cook-Granroth, Rie Maurer, Niral Shah, Joey Mansour, Juerg Tschirren and Mitchell Albert

Magnetic resonance in medicine, Vol.58(3), pp.636-642

09/2007

DOI: 10.1002/mrm.21285

PMCID: PMC2943874

PMID: 17763351

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Abstract

An anthropomorphic airway tree phantom was imaged with both hyperpolarized (HP) 3He MRI using a dynamic projection scan and computed tomography (CT). Airway diameter measurements from the HP 3He MR images obtained using a newly developed model-based algorithm were compared against their corresponding CT values quantified with a well-established method. Of the 45 airway segments that could be evaluated with CT, only 14 airway segments (31%) could be evaluated using HP 3He MRI. No airway segments smaller than approximately 4 mm in diameter and distal to the fourth generation were adequate for analysis in MRI. For the 14 airway segments measured, only two airway segments yielded a non-equivalent comparison between the two imaging modalities, while eight more had inconclusive comparison results, leaving only four airway segments (29%) that satisfied the designed equivalence criteria. Some of the potential problems in airway diameter quantification described in the formulation of the model-based algorithm were observed in this study. These results suggest that dynamic projection HP 3He MRI may have limited utility for measuring airway segment diameters, particularly those of the central airways.

Humans

Radiographic Image Enhancement - methods

Magnetic Resonance Imaging - methods

Tomography, X-Ray Computed - methods

Image Processing, Computer-Assisted - methods

Helium

Computer Graphics

Algorithms

Bronchi - anatomy & histology

Image Enhancement - methods

Phantoms, Imaging

Pulmonary Alveoli - anatomy & histology

Isotopes

Lung - anatomy & histology

Trachea - anatomy & histology

Details

Title: Subtitle: Comparison of airway diameter measurements from an anthropomorphic airway tree phantom using hyperpolarized 3He MRI and high-resolution computed tomography
Creators: Yang-Sheng Tzeng - Department of Radiology, Brigham and Women's Hospital, and Department of Biomedical Engineering, Boston University, Massachusetts, USA
Eric Hoffman
Janice Cook-Granroth
Rie Maurer
Niral Shah
Joey Mansour
Juerg Tschirren
Mitchell Albert
Resource Type: Journal article
Publication Details: Magnetic resonance in medicine, Vol.58(3), pp.636-642
Publisher: United States
DOI: 10.1002/mrm.21285
PMID: 17763351
PMCID: PMC2943874
ISSN: 0740-3194
eISSN: 1522-2594
Grant note: R33-EB001689 / NIBIB NIH HHS R33 EB001689-02 / NIBIB NIH HHS R33 EB001689 / NIBIB NIH HHS
Language: English
Date published: 09/2007
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051991602771

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