Comparison of alendronate vs alendronate plus mechanical loading as prophylaxis for osteoporosis in lung transplant recipients : a pilot study

Randy W BRAITH; Jill A CONNER; Michael N FULTON; Clem F LISOR; Darren P CASEY; Kathy S HOWE; Maher A BAZ

doi:10.1016/j.healun.2006.11.004

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Comparison of alendronate vs alendronate plus mechanical loading as prophylaxis for osteoporosis in lung transplant recipients : a pilot study

Journal article

Peer reviewed

Comparison of alendronate vs alendronate plus mechanical loading as prophylaxis for osteoporosis in lung transplant recipients : a pilot study

Randy W BRAITH, Jill A CONNER, Michael N FULTON, Clem F LISOR, Darren P CASEY, Kathy S HOWE and Maher A BAZ

The Journal of heart and lung transplantation, Vol.26(2), pp.132-137

2007

DOI: 10.1016/j.healun.2006.11.004

PMID: 17258146

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Abstract

Background: Osteoporosis is known to complicate outcomes after lung transplantation (Tx). Methods: To determine the efficacy of bisphosphonate therapy combined with the osteogenic stimulus of mechanical loading, 30 lung transplant recipients (LTRs) were randomly assigned either to alendronate (10 mg/day; n = 10), alendronate (10 mg/day) + resistance exercise (n = 10) or to a control group (n = 10). Alendronate was initiated at 7 days after Tx. Bone mineral density (BMD) of the lumbar spine was measured by dual-energy X-ray absorptiometry before and 2 and 8 months after Tx. Resistance training was initiated at 2 months after Tx and consisted of lumbar extension exercise performed 1 day/week for 6 months. Results: Lumbar BMD decreased significantly to below pre-transplant baseline at 2 months after Tx in controls (-12.5 +/- 2.1%), but not in the alendronate (1.5 +/- 1.2%) or alendronate + training (1.5 +/- 0.9%) groups. At 8 months after Tx, lumbar BMD in controls was 14.1 +/- 3.9% below baseline (p < or = 0.05), but was 1.4 +/- 1.1% above baseline in alendronate recipients (p > or = 0.05). The alendronate + training group showed a significantly increased lumbar BMD with values 10.8 +/- 2.3% greater than before Tx. Conclusions: These results suggest that resistance exercise plus alendronate is more effective than alendronate alone in restoring BMD. Anti-osteoporosis therapy in LTRs should include both an anti-resorptive agent and an osteogenic stimulus, such as mechanical loading.

Osteoporosis. Osteomalacia. Paget disease

Biological and medical sciences

Medical sciences

Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases

Surgery of the heart

Diseases of the osteoarticular system

Details

Title: Subtitle: Comparison of alendronate vs alendronate plus mechanical loading as prophylaxis for osteoporosis in lung transplant recipients : a pilot study
Creators: Randy W BRAITH - Department of Applied Physiology, University of Florida, Gainesville, Florida, United States
Jill A CONNER - Department of Applied Physiology, University of Florida, Gainesville, Florida, United States
Michael N FULTON - Department of Applied Physiology, University of Florida, Gainesville, Florida, United States
Clem F LISOR - Department of Applied Physiology, University of Florida, Gainesville, Florida, United States
Darren P CASEY - Department of Applied Physiology, University of Florida, Gainesville, Florida, United States
Kathy S HOWE - Department of Applied Physiology, University of Florida, Gainesville, Florida, United States
Maher A BAZ - Department of Applied Physiology, University of Florida, Gainesville, Florida, United States
Resource Type: Journal article
Publication Details: The Journal of heart and lung transplantation, Vol.26(2), pp.132-137
Publisher: Elsevier Science; New York, NY
DOI: 10.1016/j.healun.2006.11.004
PMID: 17258146
ISSN: 1053-2498
eISSN: 1557-3117
Language: English
Date published: 2007
Academic Unit: Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984047692102771

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