Journal article
Comparison of bone regeneration in a rabbit skull defect by recombinant human BMP-2 incorporated in biodegradable hydrogel and in solution
Journal of biomaterials science. Polymer ed, Vol.9(9), pp.1001-1014
01/01/1998
DOI: 10.1163/156856298X00307
PMID: 9747991
Abstract
The objective of this study is to compare bone regeneration induced by recombinant human bone morphogenetic protein-2 (rhBMP-2) incorporated into a biodegradable gelatin hydrogel with that by rhBMP-2 in aqueous solution. After treating rabbit skull defects of 6 mm diameter with the
two rhBMP-2 dosage forms, both of them increased the bone mineral density (BMD) at the skull defects with implantation time to a significantly higher extent than a rhBMP-2-free aqueous solution and a rhBMP-2-free empty gelatin hydrogel (p < 0.05). There was no quantifiable difference in
BMD between the two dosage forms of rhBMP-2. Histological examination revealed that the integrity of newly generated bone increased with the rhBMP-2 dose, irrespective of the dosage form. The bone defect was filled with regenerated bone 21 days after treatment.
Details
- Title: Subtitle
- Comparison of bone regeneration in a rabbit skull defect by recombinant human BMP-2 incorporated in biodegradable hydrogel and in solution
- Creators
- Liu Hong - Kyoto UniversityYasuhiko Tabata - Kyoto UniversityMasaya Yamamoto - Kyoto UniversitySusumu Miyamoto - Kyoto UniversityKeisuke Yamada - Kyoto UniversityNobuo Hashimoto - Kyoto UniversityYoshito Ikada - Kyoto University
- Resource Type
- Journal article
- Publication Details
- Journal of biomaterials science. Polymer ed, Vol.9(9), pp.1001-1014
- DOI
- 10.1163/156856298X00307
- PMID
- 9747991
- NLM abbreviation
- J Biomater Sci Polym Ed
- ISSN
- 0920-5063
- eISSN
- 1568-5624
- Publisher
- Taylor & Francis Group
- Language
- English
- Date published
- 01/01/1998
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Prosthodontics; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984367625202771
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