Journal article
Comparison of clinical characteristics and outcomes of hospitalized patients with seasonal coronavirus infection and COVID-19: a retrospective cohort study
BMC infectious diseases, Vol.22(1), pp.618-618
07/15/2022
DOI: 10.1186/s12879-022-07555-4
PMCID: PMC9284965
PMID: 35840902
Abstract
Background Unlike SARS-CoV and MERS-C0V, SARS-CoV-2 has the potential to become a recurrent seasonal infection; hence, it is essential to compare the clinical spectrum of COVID-19 to the existent endemic coronaviruses. We conducted a retrospective cohort study of hospitalized patients with seasonal coronavirus (sCoV) infection and COVID-19 to compare their clinical characteristics and outcomes. Methods A total of 190 patients hospitalized with any documented respiratory tract infection and a positive respiratory viral panel for sCoV from January 1, 2011, to March 31, 2020, were included. Those patients were compared with 190 hospitalized adult patients with molecularly confirmed symptomatic COVID-19 admitted from March 1, 2020, to May 25, 2020. Results Among 190 patients with sCoV infection, the Human Coronavirus-OC93 was the most common coronavirus with 47.4% of the cases. When comparing demographics and baseline characteristics, both groups were of similar age (sCoV: 74 years vs. COVID-19: 69 years) and presented similar proportions of two or more comorbidities (sCoV: 85.8% vs. COVID-19: 81.6%). More patients with COVID-19 presented with severe disease (78.4% vs. 67.9%), sepsis (36.3% vs. 20.5%), and developed ARDS (15.8% vs. 2.6%) compared to patients with sCoV infection. Patients with COVID-19 had an almost fourfold increased risk of in-hospital death than patients with sCoV infection (OR 3.86, CI 1.99-7.49; p < .001). Conclusion Hospitalized patients with COVID-19 had similar demographics and baseline characteristics to hospitalized patients with sCoV infection; however, patients with COVID-19 presented with higher disease severity, had a higher case-fatality rate, and increased risk of death than patients with sCoV. Clinical findings alone may not help confirm or exclude the diagnosis of COVID-19 during high acute respiratory illness seasons. The respiratory multiplex panel by PCR that includes SARS-CoV-2 in conjunction with local epidemiological data may be a valuable tool to assist clinicians with management decisions.
Details
- Title: Subtitle
- Comparison of clinical characteristics and outcomes of hospitalized patients with seasonal coronavirus infection and COVID-19: a retrospective cohort study
- Creators
- Guillermo Rodriguez-Nava - AMITA Hlth St Francis Hosp, Dept Internal Med, 355 Ridge Ave, Evanston, IL 60202 USAGoar Egoryan - Saint Francis HospitalTianyu Dong - Saint Francis HospitalQishuo Zhang - Saint Francis HospitalElise Hyser - Saint Francis HospitalBidhya Poudel - Saint Francis HospitalMaria Adriana Yanez-Bello - AMITA Hlth St Francis Hosp, Dept Internal Med, 355 Ridge Ave, Evanston, IL 60202 USADaniela Patricia Trelles-Garcia - Saint Francis HospitalChul Won Chung - Saint Francis HospitalBimatshu Pyakuryal - Saint Francis HospitalTaraz Imani-Ramos - Saint Joseph HospitalValeria Patricia Trelles-Garcia - John H. Stroger, Jr. Hospital of Cook CountyDaniel Sebastian Bustamante-Soliz - University of CuencaJonathan J. Stake - Saint Francis Hospital
- Resource Type
- Journal article
- Publication Details
- BMC infectious diseases, Vol.22(1), pp.618-618
- Publisher
- Springer Nature
- DOI
- 10.1186/s12879-022-07555-4
- PMID
- 35840902
- PMCID
- PMC9284965
- ISSN
- 1471-2334
- eISSN
- 1471-2334
- Number of pages
- 11
- Language
- English
- Date published
- 07/15/2022
- Academic Unit
- General Internal Medicine; Internal Medicine
- Record Identifier
- 9984692640002771
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