Comparison of clinical, echographic, and histopathological measurements from eyes with medium-sized choroidal melanoma in the collaborative ocular melanoma study: COMS report no. 21

Marie Diener-West; Daniel M Albert; Sandra Frazier Byrne; Frederick H Davidorf; David Followill; Ronald L Green; Barbara S Hawkins; Peter K Kaiser; Dennis M Robertson; Bradley R Straatsma; Collaborative Ocular Melanoma Study Group

doi:10.1001/archopht.121.8.1163

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Comparison of clinical, echographic, and histopathological measurements from eyes with medium-sized choroidal melanoma in the collaborative ocular melanoma study: COMS report no. 21

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Comparison of clinical, echographic, and histopathological measurements from eyes with medium-sized choroidal melanoma in the collaborative ocular melanoma study: COMS report no. 21

Marie Diener-West, Daniel M Albert, Sandra Frazier Byrne, Frederick H Davidorf, David Followill, Ronald L Green, Barbara S Hawkins, Peter K Kaiser, Dennis M Robertson, Bradley R Straatsma, …

Archives of ophthalmology (1960), Vol.121(8), pp.1163-1171

08/01/2003

DOI: 10.1001/archopht.121.8.1163

PMID: 12912695

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Abstract

OBJECTIVE To compare pre-enucleation clinical and echographic measurements with postenucleation histopathological measurements of choroidal melanoma of a size and in a location suitable for iodine 125 brachytherapy. DESIGN Cross-sectional study of patients with melanoma classified as medium-sized who were assigned to the enucleation arm of the randomized trial of 125I brachytherapy vs enucleation conducted by the Collaborative Ocular Melanoma Study (COMS) Group. METHODS Measurements of melanoma dimensions by clinical, echographic, and histopathological examinations were compared for 644 eyes. Outcomes Tumor longest basal diameter and apical height. RESULTS Tumor dimensions were available for 644 (98%) of 660 patients who had unilateral medium-sized choroidal melanoma and were randomly assigned to enucleation. The clinical and histopathological measurements of the longest basal diameter agreed within +/-2 mm for 371 eyes (58%). The clinical measurement was less than the histopathological measurement by more than 2 mm in 32 eyes (5%), which occurred more frequently when the tumor was within 2 mm of the optic disc. The echographic and histopathological measurements of apical height agreed within +/-2 mm in 579 eyes (90%); the echographic measurement was less than the histopathological measurement in only 2 cases. Features associated with echographic estimates larger than histopathological measurements were greater tumor height and anterior tumor apex location. CONCLUSIONS Our results suggest that tumor measurements made according to COMS protocol were highly reliable in planning radioactive plaque therapy and monitoring changes in tumor size after such treatment.

Details

Title: Subtitle: Comparison of clinical, echographic, and histopathological measurements from eyes with medium-sized choroidal melanoma in the collaborative ocular melanoma study: COMS report no. 21
Creators: Marie Diener-West - COMS Coordinating Center, Wilmer Clinical Trials and Biometry
Daniel M Albert
Sandra Frazier Byrne
Frederick H Davidorf
David Followill
Ronald L Green
Barbara S Hawkins
Peter K Kaiser
Dennis M Robertson
Bradley R Straatsma
Collaborative Ocular Melanoma Study Group
Contributors: H Culver Boldt (Contributor) - University of Iowa, Ophthalmology and Visual Sciences
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.121(8), pp.1163-1171
DOI: 10.1001/archopht.121.8.1163
PMID: 12912695
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association
Language: English
Date published: 08/01/2003
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984083855002771

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