Comparison of clinical features and outcomes of Chinese patients with Takotsubo syndrome and acute myocardial infarction—results from the first Chinese Takotsubo syndrome registry

Yuxi Huang; Lingchun Lyu; Yuan Tao; Juan Lei; Yulin Wei; Liwen Wu; Mei Xu; Yusheng Liu; Lingzhi Jiang; Zhongxia Sun; Yongmin Ding; Pengfei Miao; Qianglin Guan; Feng Lv; Cunxue Pan; Chenying Lu; Yuyi Chen; Tou Kun Chong; Kan Liu; Jian Chen

doi:10.21037/cdt-2025-8

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Comparison of clinical features and outcomes of Chinese patients with Takotsubo syndrome and acute myocardial infarction—results from the first Chinese Takotsubo syndrome registry

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Comparison of clinical features and outcomes of Chinese patients with Takotsubo syndrome and acute myocardial infarction—results from the first Chinese Takotsubo syndrome registry

Yuxi Huang, Lingchun Lyu, Yuan Tao, Juan Lei, Yulin Wei, Liwen Wu, Mei Xu, Yusheng Liu, Lingzhi Jiang, Zhongxia Sun, …

Cardiovascular diagnosis and therapy, Vol.15(3), pp.563-573

06/30/2025

DOI: 10.21037/cdt-2025-8

PMCID: PMC12246995

PMID: 40656782

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Abstract

Background: Takotsubo syndrome (TTS) differs significantly from acute myocardial infarction (AMI) in clinical features and pathological mechanisms, but evidence in Asian populations remains limited. The aim of this study is to compare clinical features and outcomes between patients with TTS and AMI in the first Chinese registry of TTS (ChiTTS Registry, ChiCTR1900026725). Methods: In this multicenter 6-year retrospective cohort study (February 2016–June 2022), a total of 116 consecutive TTS patients diagnosed according to the international Takotsubo diagnostic criteria and 232 age- and sex-matched AMI patients (1:2 ratio) meeting the 2023 European Society of Cardiology guidelines criteria were enrolled from 10 tertiary medical centers across China. Clinical characteristics, in-hospital outcomes, and major adverse cardiovascular and cerebrovascular events (MACCEs) were compared between groups using Student’s t-test or Chi-squared test. Time-to-event analysis employed Kaplan-Meier/log-rank tests with landmark analysis. Results: The median follow-up time was 1.23 [interquartile range (IQR), 0.33–2.63] years in ChiTTS Registry patients and 2.35 (IQR, 1.68–3.68) years in AMI patients. In contrast to AMI patients, TTS patients presented with more clinical manifestations associated with acute heart failure. TTS patients developed approximately twice as many in-hospital complications as AMI patients (42.2% vs. 20.7%, P<0.001) and experienced significantly more 100-day MACCEs (19.6% vs. 10.8%, P=0.03) and all-cause mortality (17.9% vs. 8.9%, P=0.02). In comparison to AMI patients, the landmark analysis confirmed that TTS patients developed more 100-day MACCEs [hazard ratio (HR) 1.87; 95% confidence interval (CI): 1.03–3.37; log-rank test P=0.04] and all-cause mortality (HR 2.07; 95% CI: 1.10–3.91; log-rank test P=0.02). In contrast, no significant difference was found in long-term MACCEs (HR 0.38; 95% CI: 0.13–1.09; log-rank test P=0.06) and all-cause mortality (HR 0.96; 95% CI: 0.31–2.98; log-rank test P=0.94) between TTS and AMI patients. Conclusions: In comparison to AMI patients, Chinese TTS patients developed more in-hospital complications and had a worse short-term prognosis. The cardiovascular issues in TTS patients underscore the need for effective treatment and personalized strategies to enhance outcomes and mitigate risks.

Takotsubo syndrome (TTS)

acute myocardial infarction (AMI)

Chinese

characteristics

prognosis

Details

Title: Subtitle: Comparison of clinical features and outcomes of Chinese patients with Takotsubo syndrome and acute myocardial infarction—results from the first Chinese Takotsubo syndrome registry
Creators: Yuxi Huang
Lingchun Lyu
Yuan Tao
Juan Lei
Yulin Wei
Liwen Wu
Mei Xu
Yusheng Liu
Lingzhi Jiang
Zhongxia Sun
Yongmin Ding
Pengfei Miao
Qianglin Guan
Feng Lv
Cunxue Pan
Chenying Lu
Yuyi Chen
Tou Kun Chong
Kan Liu - Washington University in St. Louis
Jian Chen
Resource Type: Journal article
Publication Details: Cardiovascular diagnosis and therapy, Vol.15(3), pp.563-573
DOI: 10.21037/cdt-2025-8
PMID: 40656782
PMCID: PMC12246995
NLM abbreviation: Cardiovasc Diagn Ther
ISSN: 2223-3652
eISSN: 2223-3660
Publisher: AME PUBLISHING COMPANY
Number of pages: 11
Grant note: Science and Technology Development Fund, Macau SAR: 0117/2019/A3 Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine Foundation of Guangdong Province: 2023LSYS001
Funding: This work was supported by Science and Technology Development Fund, Macau SAR (No. 0117/2019/A3) and The Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine Foundation of Guangdong Province (No. 2023LSYS001) .
Language: English
Date published: 06/30/2025
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984843246402771

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