Journal article
Comparison of intensity modulated x-ray therapy and intensity modulated proton therapy for selective subvolume boosting: a phantom study
Physics in medicine & biology, Vol.52(20), pp.6073-6091
10/21/2007
DOI: 10.1088/0031-9155/52/20/001
PMCID: PMC2712448
PMID: 17921573
Abstract
Selective subvolume boosting can theoretically improve tumour control probability while maintaining normal tissue complication probabilities similar to those of uniform dose distributions. In this work the abilities of intensity modulated x-ray therapy (IMXT) and intensity modulated proton therapy (IMPT) to deliver boosts to multiple subvolumes of varying size and proximities are compared in a thorough phantom study. IMXT plans were created using the step-and-shoot (IMXT-SAS) and helical tomotherapy (IMXT-HT) methods. IMPT plans were created with the spot scanning (IMPT-SS) and distal gradient tracking (IMPT-DGT) methods. IMPT-DGT is a generalization of the distal edge tracking method designed to reduce the number of proton beam spots required to deliver non-uniform dose distributions relative to IMPT-SS. The IMPT methods were delivered over both 180° and 360° arcs. The IMXT-SAS and IMPT-SS methods least and most optimally satisfied the non-uniform dose prescriptions, respectively. The IMPT delivery methods reduced normal tissue integral dose by a factor of about two relative to the IMXT delivery methods, regardless of the delivery arc. The IMPT-DGT method reduced the number of proton beam spots by a factor of about three relative to the IMPT-SS method.
Details
- Title: Subtitle
- Comparison of intensity modulated x-ray therapy and intensity modulated proton therapy for selective subvolume boosting: a phantom study
- Creators
- R T Flynn - University of Wisconsin Department of Medical Physics, 1530 MSC, 1300 University Ave, Madison, WI 53703, USAD L Barbee - University of Wisconsin Department of Medical Physics, 1530 MSC, 1300 University Ave, Madison, WI 53703, USAT R Mackie - University of Wisconsin Department of Medical Physics, 1530 MSC, 1300 University Ave, Madison, WI 53703, USAR Jeraj - University of Wisconsin Department of Medical Physics, 1530 MSC, 1300 University Ave, Madison, WI 53703, USA
- Resource Type
- Journal article
- Publication Details
- Physics in medicine & biology, Vol.52(20), pp.6073-6091
- DOI
- 10.1088/0031-9155/52/20/001
- PMID
- 17921573
- PMCID
- PMC2712448
- NLM abbreviation
- Phys Med Biol
- ISSN
- 0031-9155
- eISSN
- 1361-6560
- Publisher
- IOP Publishing
- Language
- English
- Date published
- 10/21/2007
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047610402771
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