Journal article
Comparison of live birth rates after IVF-embryo transfer with and without preimplantation genetic testing for aneuploidies
Reproductive biomedicine online, Vol.43(6), pp.995-1001
12/01/2021
DOI: 10.1016/j.rbmo.2021.09.011
PMID: 34674943
Abstract
Research question: Does the use of preimplantation genetic testing for aneuploidies (PGT-A) result in higher live birth rates when compared with both fresh and frozen embryo transfers (FET) not utilizing PGT-A? Design: Retrospective cohort study at a single tertiary centre using inverse probability of treatment weighting (IPTW) to adjust for differences in baseline characteristics between groups. Results: A total of 107 FET using PGT-A from 74 patients, along with 321 fresh and 286 FET not using PGT-A from 381 patients met the inclusion criteria for this study. In the IPTW-adjusted analysis of transfer-level data, PGT-A transfers resulted in a significantly higher live birth rate when compared with both non-PGT-A fresh (49.5% versus 38.6%, P = 0.036) and FET (50.6% versus 35.8%, P = 0.016). When data were analysed per retrieval level, the live birth rate was similar and acceptably high with or without PGT-A (63.7% versus 52.3%, P = 0.09). Conclusion: When comparing PGT-A to non-PGT-A fresh and FET, PGT-A embryo transfers have a significantly higher live birth rate. However, this difference did not persist at a per-retrieval level. Further investigation is needed to understand in what scenarios PGT-A has clinical significance and whether differences in the number of available embryos for transfer negates the benefit of PGT-A.
Details
- Title: Subtitle
- Comparison of live birth rates after IVF-embryo transfer with and without preimplantation genetic testing for aneuploidies
- Creators
- Emily Sadecki - Mayo ClinicLaura Rust - Mayo Clinic in ArizonaDavid L. Walker - Mayo Clinic in ArizonaJolene R. Fredrickson - Mayo Clinic in ArizonaAnthony Krenik - Mayo Clinic in ArizonaTana Kim - Reprod Med & Infertil Associates, Woodbury, NY USAAmy L. Weaver - Mayo Clinic in FloridaYulian Zhao - Mayo Clinic in Arizona
- Resource Type
- Journal article
- Publication Details
- Reproductive biomedicine online, Vol.43(6), pp.995-1001
- DOI
- 10.1016/j.rbmo.2021.09.011
- PMID
- 34674943
- NLM abbreviation
- Reprod Biomed Online
- ISSN
- 1472-6483
- eISSN
- 1472-6491
- Publisher
- Elsevier
- Number of pages
- 7
- Language
- English
- Date published
- 12/01/2021
- Academic Unit
- Family and Community Medicine
- Record Identifier
- 9984959945702771
Metrics
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