Comparison of mRNA Vaccine Effectiveness against COVID-19-associated Hospitalization by Vaccination Source: Immunization Information Systems, Electronic Medical Records, and Self-Report — IVY Network, February 1August 31, 2022

Diya Surie; Levi Bonnell; Jennifer DeCuir; Manjusha Gaglani; Tresa McNeal; Shekhar Ghamande; Jay S. Steingrub; Nathan I. Shapiro; Laurence W. Busse; Matthew E. Prekker; Ithan D. Peltan; Samuel M. Brown; David N. Hager; Harith Ali; Michelle N. Gong; Amira Mohamed; Akram Khan; Jennifer G. Wilson; Nida Qadir; Steven Y. Chang; Adit A. Ginde; David Huynh; Nicholas M. Mohr; Christopher Mallow; Emily T. Martin; Adam S. Lauring; Nicholas J. Johnson; Jonathan D. Casey; Kevin W. Gibbs; Jennie H. Kwon; Adrienne Baughman; James D. Chappell; Kimberly W. Hart; Carlos G. Grijalva; Jillian P. Rhoads; Sydney A. Swan; H. Keipp Talbot; Kelsey N. Womack; Yuwei Zhu; Mark W. Tenforde; Katherine Adams; Wesley H. Self; Meredith L. McMorrow

doi:10.1016/j.vaccine.2023.05.028

Back

Comparison of mRNA Vaccine Effectiveness against COVID-19-associated Hospitalization by Vaccination Source: Immunization Information Systems, Electronic Medical Records, and Self-Report — IVY Network, February 1August 31, 2022

Journal article

Open access

Peer reviewed

Comparison of mRNA Vaccine Effectiveness against COVID-19-associated Hospitalization by Vaccination Source: Immunization Information Systems, Electronic Medical Records, and Self-Report — IVY Network, February 1August 31, 2022

Diya Surie, Levi Bonnell, Jennifer DeCuir, Manjusha Gaglani, Tresa McNeal, Shekhar Ghamande, Jay S. Steingrub, Nathan I. Shapiro, Laurence W. Busse, Matthew E. Prekker, …

Vaccine, Vol.41(29), pp.4249-4256

06/29/2023

DOI: 10.1016/j.vaccine.2023.05.028

PMCID: PMC10183633

PMID: 37301704

Files and links (1)

url

https://doi.org/10.1016/j.vaccine.2023.05.028View

Published (Version of record) Open Access

Abstract

Accurate determination of COVID-19 vaccination status is necessary to produce reliable COVID-19 vaccine effectiveness (VE) estimates. Data comparing differences in COVID-19 VE by vaccination sources (i.e., immunization information systems [IIS], electronic medical records [EMR], and self-report) are limited. We compared the number of mRNA COVID-19 vaccine doses identified by each of these sources to assess agreement as well as differences in VE estimates using vaccination data from each individual source and vaccination data adjudicated from all sources combined. Adults aged ≥18 years who were hospitalized with COVID-like illness at 21 hospitals in 18 U.S. states participating in the IVY Network during February 1*August 31, 2022, were enrolled. Numbers of COVID-19 vaccine doses identified by IIS, EMR, and self-report were compared in kappa agreement analyses. Effectiveness of mRNA COVID-19 vaccines against COVID-19-associated hospitalization was estimated using multivariable logistic regression models to compare the odds of COVID-19 vaccination between SARS-CoV-2-positive case-patients and SARS-CoV-2-negative control-patients. VE was estimated using each source of vaccination data separately and all sources combined. A total of 4,499 patients were included. Patients with ≥1 mRNA COVID-19 vaccine dose were identified most frequently by self-report (n=3,570, 79%), followed by IIS (n=3,272, 73%) and EMR (n=3,057, 68%). Agreement was highest between IIS and self-report for 4 doses with a kappa of 0.77 (95% CI = 0.73*0.81). VE point estimates of 3 doses against COVID-19 hospitalization were substantially lower when using vaccination data from EMR only (VE = 31%, 95% CI = 16%*43%) than when using all sources combined (VE = 53%, 95% CI = 41%*62%). Vaccination data from EMR only may substantially underestimate COVID-19 VE.

COVID-19

mRNA vaccines

SARS-CoV-2

test-negative study design

vaccine effectiveness

Details

Title: Subtitle: Comparison of mRNA Vaccine Effectiveness against COVID-19-associated Hospitalization by Vaccination Source: Immunization Information Systems, Electronic Medical Records, and Self-Report — IVY Network, February 1August 31, 2022
Creators: Diya Surie - National Center for Immunization and Respiratory Diseases
Levi Bonnell - National Center for Immunization and Respiratory Diseases
Jennifer DeCuir - National Center for Immunization and Respiratory Diseases
Manjusha Gaglani - Baylor Scott & White Health
Tresa McNeal - Baylor Scott & White Health
Shekhar Ghamande - Baylor Scott & White Health
Jay S. Steingrub - Baystate Medical Center
Nathan I. Shapiro - Beth Israel Deaconess Medical Center
Laurence W. Busse - Emory University
Matthew E. Prekker - Hennepin County Medical Center
Ithan D. Peltan - University of Utah
Samuel M. Brown - University of Utah
David N. Hager - Johns Hopkins Medicine
Harith Ali - Johns Hopkins Medicine
Michelle N. Gong - Albert Einstein College of Medicine
Amira Mohamed - Montefiore Health System
Akram Khan - Oregon Health & Science University
Jennifer G. Wilson - Stanford University
Nida Qadir - University of California, Los Angeles
Steven Y. Chang - University of California, Los Angeles
Adit A. Ginde - Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, United States
David Huynh - Johns Hopkins Medicine
Nicholas M. Mohr - University of Iowa
Christopher Mallow - University of Miami
Emily T. Martin - University of Michigan
Adam S. Lauring - University of Michigan
Nicholas J. Johnson - University of Washington
Jonathan D. Casey - Vanderbilt University Medical Center
Kevin W. Gibbs - Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States
Jennie H. Kwon - Department of Medicine, Washington University, St. Louis, MO, United States
Adrienne Baughman - Vanderbilt University Medical Center
James D. Chappell - Vanderbilt University Medical Center
Kimberly W. Hart - Vanderbilt University Medical Center
Carlos G. Grijalva - Vanderbilt University Medical Center
Jillian P. Rhoads - Vanderbilt University Medical Center
Sydney A. Swan - Vanderbilt University Medical Center
H. Keipp Talbot - Vanderbilt University Medical Center
Kelsey N. Womack - Vanderbilt University Medical Center
Yuwei Zhu - Vanderbilt University Medical Center
Mark W. Tenforde - National Center for Immunization and Respiratory Diseases
Katherine Adams - National Center for Immunization and Respiratory Diseases
Wesley H. Self - Vanderbilt University Medical Center
Meredith L. McMorrow - National Center for Immunization and Respiratory Diseases
Resource Type: Journal article
Publication Details: Vaccine, Vol.41(29), pp.4249-4256
DOI: 10.1016/j.vaccine.2023.05.028
PMID: 37301704
PMCID: PMC10183633
NLM abbreviation: Vaccine
ISSN: 0264-410X
eISSN: 1873-2518
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention
Language: English
Electronic publication date: 05/15/2023
Date published: 06/29/2023
Academic Unit: Epidemiology; Emergency Medicine; Anesthesia; Injury Prevention Research Center
Record Identifier: 9984413081702771

Metrics

15 Record Views

11 Times Cited - Web of Science

See more details