Journal article
Comparison of mother-to-child transmission rates in Ugandan women with subtype A versus D HIV-1 who received single-dose nevirapine prophylaxis : HIV network for prevention trials 012
Journal of acquired immune deficiency syndromes (1999), Vol.39(5), pp.593-597
2005
DOI: 10.1097/01.qai.0000155693.05830.aa
PMID: 16044013
Abstract
Objective:
To compare the rate of mother-to-child transmission (MTCT) in women with subtype A versus D HIV-1 who received single-dose nevirapine (NVP).
Methods:
The MTCT rates were compared in women with subtype A versus D at birth and at 8 weeks and 18 months of age of the infants. The rate of late MTCT (after 8 weeks of age) was also analyzed.
Results:
HIV-1 subtypes were determined for 300 of 306 women who received NVP in the HIV Network for Prevention Trials 012 study (158 women with subtype A and 105 women with subtype D). Infant infection status was known for 297 women. The cumulative rate of MTCT at 18 months was 13.2% for subtype A and 18.3% for subtype D (P = 0.34). The rate of late transmission was 3.8% for subtype A and 7.6% for subtype D (P = 0.28). Maternal baseline viral load was a significant predictor of MTCT, but maternal baseline CD4 cell count and subtype were not.
Conclusions:
No significant difference was observed in the rate of MTCT in women with subtype A versus D. There was a trend toward a higher rate of MTCT among women with subtype D, however, which was also apparent among women whose infants were infected after 8 weeks of age.
Details
- Title: Subtitle
- Comparison of mother-to-child transmission rates in Ugandan women with subtype A versus D HIV-1 who received single-dose nevirapine prophylaxis : HIV network for prevention trials 012
- Creators
- Susan H ESHLEMAN - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, United StatesLaura A GUAY - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, United StatesAnthony MWATHA - Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United StatesElizabeth BROWN - Department of Biostatistics, University of Washington, Seattle, WA, United StatesPhilippa MUSOKE - Department of Paediatrics, Makerere University, Kampala, UgandaFrancis MMIRO - Department of Obstetrics and Gynaecology, Makerere University, Kampala, UgandaJ. Brooks JACKSON - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, United States
- Resource Type
- Journal article
- Publication Details
- Journal of acquired immune deficiency syndromes (1999), Vol.39(5), pp.593-597
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1097/01.qai.0000155693.05830.aa
- PMID
- 16044013
- ISSN
- 1525-4135
- eISSN
- 1944-7884
- Language
- English
- Date published
- 2005
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047697602771
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