Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee

H. James Williams; John R Ward; Marlene J Egger; R Neuner; Raye H Brooks; Daniel O Clegg; Elizabeth H Field; John L Skosey; Graciela S Alarcón; Robert F Willkens; Harold E Paulus; I Jon Russell; John T Sharp

doi:10.1002/art.1780360904

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Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee

Journal article

Open access

Peer reviewed

Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee

H. James Williams, John R Ward, Marlene J Egger, R Neuner, Raye H Brooks, Daniel O Clegg, Elizabeth H Field, John L Skosey, Graciela S Alarcón, Robert F Willkens, …

Arthritis and rheumatism, Vol.36(9), pp.1196-1206

09/1993

DOI: 10.1002/art.1780360904

PMID: 8216413

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Abstract

To compare the relative safety and efficacy of naproxen and acetaminophen in the treatment of osteoarthritis (OA) of the knee. The major outcome measures were radiographic progression and withdrawal from the trial due to lack of efficacy. One hundred seventy-eight patients with OA of the knee were enrolled in a 2-year prospective, controlled, double-blind multicenter trial and were randomly assigned to receive acetaminophen (ACT) or naproxen (NPX) treatment. After 6 weeks of treatment, modest improvement in pain on motion and in physician's global assessment was seen in both the ACT and the NPX groups, and the NPX group also had modest improvement in pain at rest and in 50-foot walk time. Sixty-two patients completed the 2-year study. Among these patients, radiographic progression was similar in the 2 treatment groups. Withdrawal from the trial due to lack of drug efficacy was slightly more frequent among patients in the ACT group (22% versus 16%), but withdrawal due to adverse drug effects was slightly more common in the NPX group (23% versus 18%). The efficacy of ACT treatment and NPX treatment was similar, although it was slightly better for NPX. The toxicity rate was slightly lower with ACT. However, the high rate of withdrawal in both treatment groups suggests that neither is satisfactory for the treatment of OA.

Acetaminophen - adverse effects

Naproxen - adverse effects

Prospective Studies

Double-Blind Method

Humans

Knee Joint - physiopathology

Middle Aged

Knee Joint - diagnostic imaging

Osteoarthritis - diagnostic imaging

Male

Patient Dropouts

Osteoarthritis - drug therapy

Naproxen - therapeutic use

Osteoarthritis - physiopathology

Walking

Arthrography

Aged, 80 and over

Adult

Female

Aged

Acetaminophen - therapeutic use

Details

Title: Subtitle: Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee
Creators: H. James Williams - University of Utah
John R Ward
Marlene J Egger
R Neuner
Raye H Brooks
Daniel O Clegg
Elizabeth H Field
John L Skosey
Graciela S Alarcón
Robert F Willkens
Harold E Paulus - University of California, Los Angeles
I Jon Russell - The University of Texas Health Science Center at San Antonio
John T Sharp
Resource Type: Journal article
Publication Details: Arthritis and rheumatism, Vol.36(9), pp.1196-1206
DOI: 10.1002/art.1780360904
PMID: 8216413
NLM abbreviation: Arthritis Rheum
ISSN: 0004-3591
eISSN: 1529-0131
Publisher: Wiley
Grant note: NIAMS N01-AR-2264 / NIAMS NIH HHS
Language: English
Date published: 09/1993
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984094749102771

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