Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation

D C Kaluarachchi; V Y Chock; B T Do; M A Rysavy; M N Sankar; M M Laughon; C H Backes; T T Colaizy; E F Bell; P J McNamara; S R Hintz; G Natarajan

doi:10.1038/s41372-025-02417-8

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Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation

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Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation

D C Kaluarachchi, V Y Chock, B T Do, M A Rysavy, M N Sankar, M M Laughon, C H Backes, T T Colaizy, E F Bell, P J McNamara, …

Journal of perinatology, Vol.46(3), pp.370-376

03/2026

DOI: 10.1038/s41372-025-02417-8

PMCID: PMC12668793

PMID: 40987835

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Abstract

Background There is a paucity of data on neurodevelopmental outcomes in preterm infants who undergo transcatheter patent ductus arteriosus (PDA) closure (TCPC). Objective To evaluate neurodevelopmental impairment (NDI) or death at 2 years among preterm infants treated with TCPC compared to surgical ligation. Methods Retrospective cohort study of infants born at <27 weeks’ gestation at NICHD NRN sites. Comparisons were made between infants who underwent TCPC and PDA ligation. Results TCPC and surgical ligation were performed on 99 and 279 infants, respectively. Death or severe NDI occurred in 49% of infants with TCPC and 40% with surgical ligation. There was no difference in odds of death or severe NDI between the two groups [aOR 1.12 95% CI: 0.55–2.26)]. Conclusion TCPC had similar odds of death or severe NDI compared to surgical ligation. These findings need to be evaluated in large prospective studies as the management practice around the TCPC evolves. ClinicalTrials.gov ID: Generic Database: NCT00063063.

Details

Title: Subtitle: Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation
Creators: D C Kaluarachchi - University of Wisconsin–Madison
V Y Chock - Palo Alto University
B T Do - RTI International
M A Rysavy - The University of Texas Health Science Center at Houston
M N Sankar - Palo Alto University
M M Laughon - University of North Carolina at Chapel Hill
C H Backes - Nationwide Children's Hospital
T T Colaizy - University of Iowa
E F Bell - University of Iowa
P J McNamara - University of Iowa
S R Hintz - Stanford University
G Natarajan - Wayne State University
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.46(3), pp.370-376
DOI: 10.1038/s41372-025-02417-8
PMID: 40987835
PMCID: PMC12668793
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Publisher: SPRINGERNATURE
Grant note: UL1 TR6, UL1 TR41, UL1 TR42, UL1 TR77, UL1 TR93, UL1 TR105, UL1 TR442, UL1 TR454, UL1 TR1117 / U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)
Language: English
Electronic publication date: 09/23/2025
Date published: 03/2026
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984964810602771

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