Journal article
Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt
PLoS One, Vol.12(2), e0172696
02/23/2017
DOI: 10.1371/journal.pone.0172696
PMCID: PMC5322908
PMID: 28231336
Abstract
<p>Pesticide-exposed adolescents may have a higher risk of neurotoxic effects because of their developing brains and bodies. However, only a limited number of studies have addressed this risk among adolescents. The aim of this study was to compare neurological outcomes from two cohorts of Egyptian adolescents working as pesticide applicators. In 2005 and 2009, two cohorts of male adolescents working as pesticide applicators for the cotton crop were recruited from Menoufia Governorate, Egypt. The same application schedule and pesticides were used at both times, including both organophosphorus, and pyrethroid compounds. Participants in both cohorts completed three neurobehavioral tests, health and exposure questionnaires, and medical and neurological screening examinations. In addition, blood samples were collected to measure butyryl cholinesterase (BChE) activity. Pesticide applicators in both cohorts reported more neurological symptoms and signs than non-applicators, particularly among participants in the 2005 cohort (OR ranged from 1.18 to 15.3). Except for one test (Trail Making B), there were no significant differences between either applicators or non-applicators of both cohorts on the neurobehavioral outcome measures (p > 0.05). The 2005 cohort showed greater inhibition of serum BChE activity than the 2009 cohort (p < 0.05). In addition, participants with depressed BChE activity showed more symptoms and signs than others without BChE depression (p < 0.05). Our study is the first to examine the consistency of health outcomes associated with pesticide exposure across two cohorts tested at different times from the same geographical region in rural Egypt. This similar pattern of findings across the two cohorts provides strong evidence of the health impact of exposure of adolescents to pesticides.</p>
Details
- Title: Subtitle
- Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt
- Creators
- Ahmed A Ismail - University of IowaMatthew R Bonner - State University of New York at BuffaloOlfat Hendy - Menoufia University, Shebin El-Kom, EgyptGaafar Abdel Rasoul - State University of New York at BuffaloKai Wang - University of IowaJames R Olson - State University of New York at BuffaloDiane S Rohlman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- PLoS One, Vol.12(2), e0172696
- DOI
- 10.1371/journal.pone.0172696
- PMID
- 28231336
- PMCID
- PMC5322908
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Number of pages
- 13
- Copyright
- Copyright (c) 2017 Ismail et al
- Grant note
- Funder: Fogarty International Center and the National Institute of Environmental Health Sciences, Grant ID: R21 ES017223 and R01 ES022163
- Language
- English
- Date published
- 02/23/2017
- Academic Unit
- Occupational and Environmental Health; International Programs; Biostatistics; Injury Prevention Research Center
- Record Identifier
- 9983557311002771
Metrics
109 File views/ downloads
47 Record Views