Journal article
Comparison of oral immediate-release (IR) and extended-release (ER) metronidazole bactericidal activity against Bacteroides spp. using an in vitro model of infection
Diagnostic microbiology and infectious disease, Vol.37(1), pp.51-55
2000
DOI: 10.1016/S0732-8893(00)00120-6
PMID: 10794941
Abstract
We used an anaerobic infection model capable of simulating human serum pharmacokinetic parameters (C
max, C
min, half-life, and AUC) to compare the activity of oral immediate-release (IR) and extended-release (ER) MTZ formulations. Four oral regimens of MTZ plus a control regimen were simulated in the model: [i] (IR) 500 mg q8h, [ii] ER 750 mg q12h, [iii] ER 750 mg q24h, and [iv] ER 1500 mg q24h. Two clinical
Bacteroides fragilis isolates (MICs 0.5, 4.0 μg/mL) and two non-
fragilis Bacteroides isolates (MICs 0.5, 3 μg/mL) were studied. All four oral MTZ regimens exhibited rapid, bactericidal activity (≥3-log
10 decrease from the starting inoculum) within 12 h against both
fragilis and non-
fragilis Bacteroides isolates. Overall, no appreciable difference in the rate of bacteria killing was noted among the four MTZ formulations against either
B. fragilis isolates (
P = 0.907, 0.737) or non-
fragilis isolates (
P = 0.809, 0.768). We conclude that ER MTZ dosed at 12 or 24-h intervals possesses equivalent bactericidal activity to standard IR MTZ dosed every eight hours against susceptible
Bacteroides spp.
Details
- Title: Subtitle
- Comparison of oral immediate-release (IR) and extended-release (ER) metronidazole bactericidal activity against Bacteroides spp. using an in vitro model of infection
- Creators
- Russell E. Lewis - University of IowaMichael E. Klepser - University of IowaErika J. Ernst - University of IowaMichael A. Snabes - Giesecke and DevrientR.N. Jones - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Diagnostic microbiology and infectious disease, Vol.37(1), pp.51-55
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0732-8893(00)00120-6
- PMID
- 10794941
- ISSN
- 0732-8893
- eISSN
- 1879-0070
- Language
- English
- Date published
- 2000
- Academic Unit
- Pharmacy Practice and Science
- Record Identifier
- 9984365894802771
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