Journal article
Comparison of perinatal outcomes between spontaneous vs. commissioned cycles in gestational carriers for single and same-sex male intended parents
Journal of assisted reproduction and genetics, Vol.37(4), pp.953-962
04/01/2020
DOI: 10.1007/s10815-020-01728-3
PMCID: PMC7183021
PMID: 32130614
Abstract
Purpose To determine whether gestational carrier (GC) in vitro fertilization (IVF) cycles (commissioned cycles) for same-sex or single male intended parents have an increased incidence of adverse perinatal outcomes compared with spontaneous cycles in the same GCs. Design GC singleton pregnancies were identified from a database of 895 commissioned cycles from a large fertility center. Of these, 78 commissioned cycles met inclusion and exclusion criteria and were compared with 71 spontaneous cycles by the same GCs. The primary outcome was the composite score for adverse perinatal outcomes. Secondary outcomes included mode of delivery, birthweight, and gestational age. Chi-square test of association and Mann-Whitney U tests were used to compare categorical and continuous variables between the cohorts, respectively. Logistic and linear regressions controlling for GC age were constructed to determine the influence of GC cycle type on adverse perinatal outcomes. Results Commissioned cycles were significantly associated with adverse perinatal outcomes (25.6% vs. 9.9%; p = 0.02) and lower average gestational age (38.7 +/- 1.5 vs. 39.4 +/- 0.9; p < 0.001) compared with spontaneous cycles. Commissioned cycle increased the likelihood of adverse perinatal outcomes (OR 3.3; p = 0.03) and was a significant independent predictor of a lower average gestational age (beta = 0.897; p < 0.001). There were no significant differences in the incidence of vaginal deliveries or cesarean sections between commissioned and spontaneous cycles. Conclusions Commissioned cycles confer a greater incidence of composite perinatal complications and were independently associated with a lower average gestational age when compared with spontaneous pregnancies carried by the same GC despite a confirmed healthy uterine environment, sperm samples, and donor oocytes.
Details
- Title: Subtitle
- Comparison of perinatal outcomes between spontaneous vs. commissioned cycles in gestational carriers for single and same-sex male intended parents
- Creators
- Z. Pavlovic - Rush University Medical CenterK. C. Hammer - Rush University Medical CenterM. Raff - Rush University Medical CenterP. Patel - Loyola University Medical CenterK. N. Kunze - Rush University Medical CenterB. Kaplan - Fertility Centers of IllinoisC. Coughlin - aParent IVF Lab, 767 Pk Ave West,Suite 130, Highland Pk, IL 60035 USAJ. Hirshfeld-Cytron - Fertil Ctr Illinois, 900 N Kingsbury St, Chicago, IL 60610 USA
- Resource Type
- Journal article
- Publication Details
- Journal of assisted reproduction and genetics, Vol.37(4), pp.953-962
- Publisher
- Springer Nature
- DOI
- 10.1007/s10815-020-01728-3
- PMID
- 32130614
- PMCID
- PMC7183021
- ISSN
- 1058-0468
- eISSN
- 1573-7330
- Number of pages
- 10
- Language
- English
- Date published
- 04/01/2020
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984585319302771
Metrics
5 Record Views