Journal article
Comparison of real‐world outcomes following immunotherapy in recurrent or metastatic head and neck squamous cell carcinoma with outcomes of randomized controlled trials
Head & neck, Vol.45(4), pp.862-871
04/2023
DOI: 10.1002/hed.27302
PMID: 36806299
Abstract
Abstract
Objectives
Evaluate outcomes of patients with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy (IO).
Methods
Among patients with R/M HNSCC treated with IO in this retrospective single‐institution cohort, Cox regression was used to compare overall survival (OS) for those with platinum‐refractory disease and those treated in the first‐line setting with OS from KEYNOTE‐040/048, respectively. Multivariable Cox regression was used to identify predictors of OS.
Results
There was no significant OS difference for those treated in the platinum‐refractory setting when compared to patients on KEYNOTE‐040 (HR = 1.22,
p
= 0.27), nor for the first‐line setting compared to KEYNOTE‐048 (HR = 1.23,
p
= 0.19). ECOG‐PS 1 (HR = 2.00,
p
= 0.02) and ECOG‐PS 2 (HR = 3.13,
p
< 0.01) were associated with worse OS. Higher absolute lymphocyte count (ALC) was associated with improved OS (HR = 0.93 per 100 cells/μL,
p
= 0.03).
Conclusions
Real‐world outcomes of IO in R/M HNSCC are similar to outcomes in randomized control trials, with performance status and ALC correlating with OS.
Details
- Title: Subtitle
- Comparison of real‐world outcomes following immunotherapy in recurrent or metastatic head and neck squamous cell carcinoma with outcomes of randomized controlled trials
- Creators
- Anirudh Yalamanchali - Cleveland ClinicKailin Yang - Cleveland ClinicLogan Roof - Cleveland ClinicNerea Lopetegui-Lia - Cleveland ClinicLarisa M. Schwartzman - Cleveland ClinicShauna R. Campbell - Cleveland ClinicNeil M. Woody - Cleveland ClinicNatalie Silver - Cleveland ClinicShlomo Koyfman - Cleveland ClinicJessica L. Geiger - Cleveland ClinicEmrullah Yilmaz - Cleveland Clinic
- Resource Type
- Journal article
- Publication Details
- Head & neck, Vol.45(4), pp.862-871
- DOI
- 10.1002/hed.27302
- PMID
- 36806299
- ISSN
- 1043-3074
- eISSN
- 1097-0347
- Language
- English
- Date published
- 04/2023
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984696716002771
Metrics
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