Comparison of response evaluation criteria in solid tumors with volumetric measurements for estimation of tumor burden in pancreatic adenocarcinoma and hepatocellular carcinoma

Jessemae L Welsh; Kellie Bodeker; Elizabeth Fallon; Sundershan K Bhatia; John M Buatti; Joseph J Cullen

doi:10.1016/j.amjsurg.2012.07.007

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Comparison of response evaluation criteria in solid tumors with volumetric measurements for estimation of tumor burden in pancreatic adenocarcinoma and hepatocellular carcinoma

Journal article

Peer reviewed

Comparison of response evaluation criteria in solid tumors with volumetric measurements for estimation of tumor burden in pancreatic adenocarcinoma and hepatocellular carcinoma

Jessemae L Welsh, Kellie Bodeker, Elizabeth Fallon, Sundershan K Bhatia, John M Buatti and Joseph J Cullen

The American journal of surgery, Vol.204(5), pp.580-585

11/2012

DOI: 10.1016/j.amjsurg.2012.07.007

PMCID: PMC3496005

PMID: 22902100

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Abstract

Response evaluation criteria in solid tumors (RECIST) is the accepted method for determining tumor progression. However, RECIST may not estimate disease burden accurately because the axial plane often does not produce the actual longest diameter. Volumetric measurements may be an alternative to better determine tumor size. Our aim was to compare volumetric measurements with RECIST in pancreatic ductal adenocarcinomas (PDA) and hepatocellular carcinomas (HCC). RECIST and volumetric measurements were determined in 9 patients with metastatic PDA and 17 patients with HCC who subsequently underwent liver transplantation. Gross pathologic measurements after hepatectomy also were analyzed for volumes. Three-dimensional diameter in volumetric analysis was 38% and 36% higher than RECIST diameter in PDA and HCC, respectively (P < .01). However, RECIST yielded 78% and 23% larger estimated tumor volumes than volumetric analysis in PDA and HCC, respectively (P < .01). Gross pathologic volume in HCC showed a linear correlation with both volumetric analysis (r = .95; P < .01) and RECIST (r = .96; P < .01) but RECIST significantly overestimated gross pathologic volume by an average of 28% (P < .01) whereas volumetric analysis was similar to gross pathologic volume (P = .56). In categorizing treatment response in PDA, RECIST and volumetric analysis were in moderate agreement (κ = .49). RECIST significantly may overestimate tumor burden compared with volumetric measurements in both PDA and HCC. Volumetric analysis may be the preferred method to detect tumor progression.

Hepatocellular carcinoma

RECIST

Volumetry

Pancreatic cancer

Details

Title: Subtitle: Comparison of response evaluation criteria in solid tumors with volumetric measurements for estimation of tumor burden in pancreatic adenocarcinoma and hepatocellular carcinoma
Creators: Jessemae L Welsh - Department of Surgery, University of Iowa College of Medicine, 200 Hawkins Dr., Iowa City, IA 52242, USA
Kellie Bodeker - Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA, USA
Elizabeth Fallon - Department of Gastroenterology, University of Iowa College of Medicine, Iowa City, IA, USA
Sundershan K Bhatia - Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA, USA
John M Buatti - Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA, USA
Joseph J Cullen - Department of Surgery, University of Iowa College of Medicine, 200 Hawkins Dr., Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: The American journal of surgery, Vol.204(5), pp.580-585
DOI: 10.1016/j.amjsurg.2012.07.007
PMID: 22902100
PMCID: PMC3496005
NLM abbreviation: Am J Surg
ISSN: 0002-9610
eISSN: 1879-1883
Publisher: Elsevier Inc
Grant note: T32 CA148062; U01 CA140206 / National Institutes of Health
Language: English
Date published: 11/2012
Academic Unit: Surgery; Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984040206702771

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