Comparison of risperidone with olanzapine in elderly patients with dementia and psychosis

Vicki L Ellingrod; Susan K Schultz; Karen Ekstam-Smith; Eric Kutscher; Carolyn Turvey; Stephan Arndt

doi:10.1592/phco.22.1.1.33496

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Journal article

Comparison of risperidone with olanzapine in elderly patients with dementia and psychosis

Vicki L Ellingrod, Susan K Schultz, Karen Ekstam-Smith, Eric Kutscher, Carolyn Turvey and Stephan Arndt

Pharmacotherapy, Vol.22(1), pp.1-5

01/2002

DOI: 10.1592/phco.22.1.1.33496

PMID: 11794418

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Abstract

To compare the effects of risperidone and olanzapine on cognition in elderly patients with dementia and psychosis, and to compare the side effects of these drugs. Single-blind, multicenter, observational study. Four rural nursing care facilities. Nineteen elderly patients with dementia and psychosis. Eleven patients were treated with risperidone, eight with olanzapine. Rating assessments were completed at baseline, 1 month, and 2 months. Simple paired and unpaired t tests determined between- and within-group differences. Social functioning, including activities of daily living, improved over baseline in both groups (p=0.03). Cognition declined significantly (p<0.05) in the risperidone group; comparatively more side effects occurred and blood pressure decreased (p<0.05) in the olanzapine group. When compared with each group cross-sectionally at baseline and end point, however, the two groups did not differ significantly. Improvements in social functioning in all 19 patients suggest that both risperidone and olanzapine may help improve functioning in elderly patients with dementia and psychosis. Cognitive and side effect profiles of these drugs may differ substantially. Further study is needed to determine patient subpopulations who may be able to tolerate one drug over another.

Single-Blind Method

Dementia - psychology

Psychotic Disorders - complications

Antipsychotic Agents - adverse effects

Humans

Middle Aged

Male

Psychotic Disorders - physiopathology

Risperidone - therapeutic use

Antipsychotic Agents - therapeutic use

Risperidone - adverse effects

Aged, 80 and over

Female

Pirenzepine - adverse effects

Dementia - drug therapy

Pirenzepine - therapeutic use

Psychotic Disorders - psychology

Pirenzepine - analogs & derivatives

Treatment Outcome

Cognition - drug effects

Benzodiazepines

Iowa

Dementia - complications

Aged

Psychotic Disorders - drug therapy

Details

Title: Subtitle: Comparison of risperidone with olanzapine in elderly patients with dementia and psychosis
Creators: Vicki L Ellingrod - College of Pharmacy, University of Iowa, Iowa City, USA. vicki-ellingrod@uiowa.edu
Susan K Schultz
Karen Ekstam-Smith
Eric Kutscher
Carolyn Turvey
Stephan Arndt
Resource Type: Journal article
Publication Details: Pharmacotherapy, Vol.22(1), pp.1-5
DOI: 10.1592/phco.22.1.1.33496
PMID: 11794418
NLM abbreviation: Pharmacotherapy
ISSN: 0277-0008
eISSN: 1875-9114
Publisher: United States
Language: English
Date published: 01/2002
Academic Unit: Psychiatry; Epidemiology; Biostatistics; Nursing; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984004187002771

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