Journal article
Comparison of the Serum and Intracellular Pharmacokinetics of Azithromycin in Healthy and Diabetic Volunteers
Pharmacotherapy, Vol.20(6), pp.657-661
06/2000
DOI: 10.1592/phco.20.7.657.35176
PMID: 10853621
Abstract
Study Objective. To compare serum and intracellular pharmacokinetics of azithromycin in healthy volunteers and patients with diabetes. Design. Open- label, parallel study. Setting. Clinical research center. Subjects. Twelve patients with diabetes and 12 healthy volunteers. Interventions. Subjects were given a single 500-mg dose of azithromycin followed by 250 mg/day for 2 days. Blood samples were obtained just before and after the third dose for up to 24 hours for serum and 168 hours for intracellular measurement of azithromycin. Measurements and Main Results. Pharmacokinetic parameters were calculated by noncompartmental methods and compared with a t test. The groups did not differ in maximum concentration, time to maximum concentration, or area under the concentration-time curve in serum or polymorphonuclear cells (PMNs). Differences in the PMN:serum ratio were observed at the 24-hour time point (healthy 1209 ± 432, diabetic 859 ± 286, p = 0.051). Conclusion. In general, the pharmacokinetics of azithromycin are comparable in diabetics and healthy volunteers. Accumulation of drug in macrophages was slightly lower in patients.
Details
- Title: Subtitle
- Comparison of the Serum and Intracellular Pharmacokinetics of Azithromycin in Healthy and Diabetic Volunteers
- Creators
- Erika J. Ernst - University of IowaMichael E. Klepser - University of IowaTeresa B. Klepser - University of IowaCharles H. Nightingale - Hartford HospitalLawrence G. Hunsicker - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pharmacotherapy, Vol.20(6), pp.657-661
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1592/phco.20.7.657.35176
- PMID
- 10853621
- ISSN
- 0277-0008
- eISSN
- 1875-9114
- Number of pages
- 5
- Language
- English
- Date published
- 06/2000
- Academic Unit
- Pharmacy Practice and Science; Nephrology; Internal Medicine
- Record Identifier
- 9984365905102771
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