Journal article
Comparison of the effectiveness of frontline chemoimmunotherapy regimens for follicular lymphoma used in the United States
Leukemia & lymphoma, Vol.56(5), pp.1295-1302
05/04/2015
DOI: 10.3109/10428194.2014.953144
PMID: 25263322
Abstract
To compare the effectiveness of frontline rituximab-chemotherapy regimens in clinical practice, we examined outcomes for patients with low-grade, stage III/IV follicular lymphoma receiving rituximab (R) with cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP), R with cyclophosphamide, vincristine and prednisone (R-CVP) or R with a fludarabine-based regimen (R-Flu) as frontline therapy. In total, 611 patients meeting these criteria were identified in the National LymphoCare Study: 47% receiving R-CHOP (n = 287), 31% receiving R-CVP (n = 187) and 22% receiving R-Flu (n = 137). Overall response rates were high (R-CVP 87%, R-CHOP 93%, R-Flu 94%; p = 0.017). Median follow-up was 7.4 years. R-CVP was associated with lower 5-year overall survival (R-CVP 76%, R-CHOP 86%, R-Flu 86%; p = 0.021) and progression-free survival (R-CVP 49%, R-CHOP 58%, R-Flu 64%; p = 0.029). There were no significant differences in survival in Cox models adjusted for baseline clinical factors, practice region/setting and post-treatment R maintenance/observation.
Details
- Title: Subtitle
- Comparison of the effectiveness of frontline chemoimmunotherapy regimens for follicular lymphoma used in the United States
- Creators
- Loretta J Nastoupil - The University of Texas M. D. Anderson Cancer CenterRajni Sinha - University Oncology and Hematology AssociatesMichelle Byrtek - Genentech/RocheRyan Ziemiecki - Biostatistics, RTI Health SolutionsMichael Taylor - GenentechJonathan W Friedberg - James P. Wilmot Cancer Center, University of RochesterJean L Koff - Emory University School of Medicine, Winship Cancer InstituteBrian K Link - University of Iowa, Holden Comprehensive Cancer CenterJames R Cerhan - Department of Health Sciences Research, Mayo ClinicKeith L Dawson - Genentech/RocheChristopher R Flowers - Emory University School of Medicine, Winship Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Leukemia & lymphoma, Vol.56(5), pp.1295-1302
- Publisher
- Taylor & Francis
- DOI
- 10.3109/10428194.2014.953144
- PMID
- 25263322
- ISSN
- 1042-8194
- eISSN
- 1029-2403
- Language
- English
- Date published
- 05/04/2015
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984094369502771
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